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研究業績(論文 1999年以前)

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h4 1999

  1. Diversity of Rearrangement of 3-Substituted 5-Carbamoyl-1-phenyluracil Derivatives.
    Hironao Sajiki, Yoshiaki Fujita, Itaru Niimoto, Kosaku Hirota
    Heterocycles, 50, 385-392 (1999)
  2. Pd/C(en)-catalyzed Regioselective Hydrogenolysis of Terminal Epoxides to Secondary Alcohols.
    Hironao Sajiki, Kazuyuki Hattori, Kosaku Hirota
    Chem. Commun., 1041-1042 (1999)
  3. Regioselective Modification of the Sugar Moiety in Pyrimidine Nucleosides via 4’,5’-Dehydro-2’,3’-epoxyuridine Intermediates.
    Kosaku Hirota , Hideki Takasu, Yoshie Tsuji, Hironao Sajiki
    Chem. Commun., 1827-1828 (1999)

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h4 1998

  1. Easy and partial hydrogenation of aromatic carbonyls to benzyl alcohols using Pd/C(ethylenediamine)-catalyst.
    Sajiki, Hironao; Hattori, Kazuyuki; Hirota, Kosaku.
    Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry, 24, 4043-4044 (1998),
  2. A novel type of Pd/C-catalyzed hydrogenation using a catalyst poison: chemoselective inhibition of the hydrogenolysis of O-benzyl protective groups by the addition of a nitrogen-containing base.
    Sajiki, Hironao; Hirota, Kosaku.
    Tetrahedron, 54(46), 13981-13996 (1998).
  3. The Formation of a Novel Pd/C-Ethylenediamine Complex Catalyst: Chemoselective Hydrogenation without Deprotection of the O-Benzyl and N-Cbz Groups.
    Sajiki, Hironao; Hattori, Kazuyuki; Hirota, Kosaku.
    Journal of Organic Chemistry, 63(22), 7990-7992 (1998).
  4. Suppression effect of the Pd/C-catalyzed hydrogenolysis of a phenolic benzyl protective group by the addition of nitrogen-containing bases.
    Sajiki, Hironao; Kuno, Hiroko; Hirota, Kosaku.
    Tetrahedron Letters, 39(39), 7127-7130 (1998).
  5. A convenient synthesis of acyclic adenosines with an unsaturated side chain by modification of 9-(2,3-O-isopropylidene-D-ribityl)adenine.
    Hirota, Kosaku; Monguchi, Yasunari; Sajiki, Hironao; Yatome, Chizuko; Hiraoka, Akio; Kitade, Yukio.
    Nucleosides & Nucleotides, 17(8), 1333-1345 (1998).
  6. Convenient synthesis of pyrido[4,3-d]pyrimidine-2,4(1H,3H)-diones.
    Hirota, Kosaku; Nakazawa, yukio; Kitade, Yukio; Sajiki, Hironao.
    Heterocycles, 47(2), 871-882 (1998).
  7. Synthesis of 5-arylthiouridines via electrophilic substitution of 5-bromouridines with diaryl disulfides.
    Hirota, Kosaku; Tomishi, Tetsuo; Maki, Yoshifumi; Sajiki, Hironao.
    Nucleosides & Nucleotides, 17(1-3), 161-173 (1998)
  8. Facile method for the preparation of 7-methyl-8-oxoguanosines as an immunomodulator.
    Kitade, Yukio; Saito, Naohiro; Kozaki, Atushi; Takahashi, Kazumasa; Yatome, Chizuko; Takeda, Yoshifumi; Sajiki, Hironao; Hirota, Kosaku.
    Nucleosides & Nucleotides, 17(1-3), 91-97 (1998)
  9. Novel synthesis of purine acyclonucleosides posessing a chiral 9-hydroxyalkyl group by sugar modification of 9-D-ribitylpurines.
    Kosaku Hirota, Yasunari Monguchi, Hironao Sajiki, Magoichi Sako, Yukio Kitade
    J. Chem. Soc., Perkin Trans. 1, 941-946 (1998)

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h4 1997

  1. High chemical reactivity of 5-azidouracils and its synthetic application: novel synthesis of 8-substituted 1,3-dimethylxanthine derivatives.
    Hirota, Kosaku; Sako, Magoichi; Sajiki, Hironao.
    Heterocycles, 46 547-554 (1997)
  2. A new synthesis of pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-diones by oxidative N-N bond formation of 6-amino-5-(N-aryliminomethyl)uracils using iodobenzene diacetate.
    Sajiki, Hironao; Hattori, Kazuyuki; Sako, Magoichi; Hirota, Kosaku.
    Synlett, 12, 1409-1410 (1997)
  3. Ribofuranose-ring cleavage of purine nucleosides with diisobutylaluminum hydride: convenient method for the preparation of purine acyclonucleosides.
    Hirota, Kosaku; Monguchi, Yasunari; Kitade, Yukio; Sajiki, Hironao.
    Tetrahedron, 53(49), 16683-16698 (1997)
  4. A novel approach for the synthesis of purine acyclonucleosides using 9-D-ribitylpurines as a chiral pool.
    Hirota, Kosaku; Monguchi, Yasunari; Sajiki, Hironao; Kitade, Yukio.
    Synlett, 6, 697-798 (1997)
  5. Reactivity of Thioaldehydes: Cyclization Reaction of 6-Amino-1,3-dimethyl-5-(thioformyl)uracil with Enamines to Form Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones.
    Hirota, Kosaku; Kubo, Keiko; Sajiki, Hironao; Kitade, Yukio; Sako, Magoichi; Maki, Yoshifumi.
    Journal of Organic Chemistry, 62(9), 2999-3001(1997)
  6. Reactivities of 6-amino-1,3-dimethyl-5-thioformyluracil toward nucleophiles and its application to synthesis of pyrido[2,3-d]pyrimidines.
    Hirota, Kosaku; Kubo, Keiko; Sajiki, Hironao.
    Chemical & Pharmaceutical Bulletin, 45(3), 542-544 (1997)
  7. Chemoselective inhibition of the hydrogenolysis of the MPM protective group for phenolic hydroxy functions using a Pd/C-pyridine catalyst.
    Sajiki, Hironao; Kuno, Hiroko; Hirota, Kosaku.
    Tetrahedron Letters, 38(3), 399-402 (1997)

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h4 1996

  1. Synthesis of Enantiomerically Pure 1-(R)- and 1-(S)-Hydroxymethyl-DTPA Penta t-Butyl Ester via Chiral Aminoalcohols.
    Hironao Sajiki, Karen Y. Ong, Samuel T. Nadler, Heather E. Weges, Thomas J. McMurry
    Synth. Commun., 26, 2511-2522 (1996).
  2. MS-325: A Small-molecule Vascular Imaging Agent for Magnetic Resonance Imaging.
    R. B.Lauffer, D. J. Parmelee, H. S. Ouelett, R. P. Dolan, Hironao Sajiki, D. M. Scott, P. J. Bernard, E. M. Buchanan, K. Y. Ong, Z. Tyeklar, K. S. Midelfort, T. J. McMurry, R. C. Walovitch
    Academic Radiology, 3, Suppl 2, S356-358 (1996)
  3. Stable Thioaldehydes: Synthesis, Structure Assignment, and Stability of 6-Amino-5-thioformyluracils.
    Kosaku Hirota, Hironao Sajiki, Keiko Kubo, Masaru Kido, Kazuyuki Nakagawa
    Tetrahedron, 52, 9971-9978 (1996)
  4. Synthesis of C2-Symmetric (S,S)-1,4-Dibenzyl-DTPA and 1,4-meso-Dibenzyl-DTPA via Chiral Diamines.
    Hironao Sajiki, Karen Y. Ong
    Tetrahedron
    , 52, 14507-14514 (1996)

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h4 1995年以前

  1. Selective Inhibition of Benzyl Ether Hydrogenolysis with Pd/C Due to the Presence of Ammonia, Pyridine and Ammonium Acetate.
    Hironao Sajiki
    Tetrahedron Lett., 36, 3465-3468 (1995)
  2. Novel Intermolecular Rearrangement of 5-Carbamoyluracils into Barbituric Acids.
    Kosaku Hirota, Hironao Sajiki, Pei-Zhou Ni, Yukio Kitade, Yoshifumi Maki
    Tetrahedron, 46, 3431-3438 (1990)
  3. Novel Reaction of Uracil Derivatives Possessing Electron Withdrawing Group at 5-Position with Amines.
    Kosaku Hirota, Yukio Kitade, Hironao Sajiki, Yoshifumi Maki
    J. Chem. Soc., Perkin Trans. 1, 367-373 (1990)
  4. Novel Ring Transformation of 5-Cyanouracils into 2-Thiocytosines, 2,4-Diaminopyrimidines, and Pyrimido[4,5-d]pyrimidines by the Reaction with Thioureas and Guanidines.
    Kosaku Hirota, Hironao Sajiki, Yukio Kitade, Yoshifumi Maki
    J. Chem. Soc., Perkin Trans. 1. 123-128 (1990)
  5. Diversity of the C-C Bond Formation in the Reaction of 5-Bromouracils with Carbanions.
    Kosaku Hirota, Hironao Sajiki, Yoshifumi Maki, Hideo Inoue, Tohru Ueda
    J. Chem. Soc., Chem. Commun., 1659-1660 (1989)
  6. A Novel Ring Transformation of 5-Carbamoyluracils into Barbituric Acids.
    Kosaku Hirota, Hironao Sajiki, Yukio Kitade, Yoshifumi Maki
    J. Chem. Soc., Perkin Trans.1, 1695-1697 (1989)
  7. Rearrangement of 5-Cyanouracils into 6-Aminouracils by Reaction with Amines and Hydroxide Ion.
    Kosaku Hirota, Hironao Sajiki, Yukio Kitade, Yoshifumi Maki
    Chem. Pharm. Bull., 37, 2008-2011 (1989)
  8. Pyrimidines. Part 57. A Versatile Synthesis of Pyrimido[4,5-d] pyrimidine-2,4,5-trione Derivatives.
    Kosaku Hirota, Jiazi Huang, Hironao Sajiki, Yoshifumi Maki
    Heterocycles, 24, 2293-2298 (1986)
  9. Novel Reaction of 5-Nitro(or carbamoyl)uracil Derivatives with Amines. Thermal Exchange Reaction of N1-portion of the Uracils for Amines via Ring-opening and Ring-closure Processes.
    Kosaku Hirota, Yukio Kitade, Hironao Sajiki, Yoshifumi Maki
    Tetrahedron Lett., 27, 3263-3266 (1986)
  10. Novel Synthesis of 2-Thiocytosine Derivatives via Pyrimidine-to-pyrimidine Ring Transformation.
    Kosaku Hirota, Yukio Kitade, Hironao Sajiki, Yoshifumi Maki
    Heterocycles, 22, 2259-2262 (1984)
  11. A Facile Synthesis of 7-Substituted Pyrimido[4,5-d]pyrimidine-2,4-diones.
    Kosaku Hirota, Yukio Kitade, Hironao Sajiki, Yoshifumi Maki
    Synthesis, 589-590 (1984)

 

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