Since 2009 to current

<2017>

34. Yasumasa Ikeda, Yuya Horinouchi, Hirofumi Hamano, Tasuku Hirayama, Seiji Kishi, Yuki Izawa-Ishizawa, Masaki Imanishi, Yoshito Zamami, Kenshi Takechi, Licht Miyamoto, Keisuke Ishizawa, Ken-ichi Aihara, Hideko Nagasawa, Koichiro Tsuchiya, Toshiaki Tamaki*
“Dietary iron restriction alleviates renal tubulointerstitial injury induced by protein overload in mice”
Sci. Rep. 2017, 7, 10621. doi: 10.1038/s41598-017-11089-0【open article】

33. Tasuku Hirayama,* Hitomi Tsuboi, Masato Niwa, Ayaji Miki, Satoki Kadota, Yukie Ikeshita, Kensuke Okuda, Hideko Nagasawa*
“A universal fluorogenic switch for Fe(II) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells”
Chem. Sci. 2017, 8, 4858–4866. doi: 10.1039/C6SC05457A【open article】

32. Keisuke Oshima, Yasumasa Ikeda, Yuya Horinouchi, Hiroaki Watanabe, Hirofumi Hamano, Yoshitaka Kihira, Seiji Kishi, Yuki Izawa-Ishizawa, Licht Miyamoto, Tasuku Hirayama, Hideko Nagasawa, Keisuke Ishizawa, Koichiro Tsuchiya, Toshiaki Tamaki*
“Iron suppresses erythropoietin expression via oxidative stress-dependent hypoxia-inducible factor-2 alpha inactivation”
Lab. Invest. 2017, 97, 555–566. doi: 10.1038/labinvest.2017.11

31. Tasuku Hirayama*, Hideko Nagasawa
[review] “Chemical tools for detection of Fe ions
J. Clin. Biochem. Nut. 2017, 60, 39–48.

<2016>

30. 平山 祐
【紹介記事】「Click-EM—生体分子を電子顕微鏡で観察する新しい手法」
News & Hot Paper Digest、実験医学、2016、Vol. 34、No.19(12月号)、3170–3171

29. 平山 祐
【総説】「蛍光プローブ分子を使った生細胞での高感度二価鉄検出」
化学工業第67巻、p.41–47、2016年8月

28. Fumiya Ito, Takahiro Nishiyama, Lei Shi, Masahiko Mori, Tasuku Hirayama, Hideko Nagasawa, Hiroyuki Yasui, Shinya Toyokuni*
“Contrasting intro-and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis”
Biochem. Biophys. Res. Commun. 2016, 476, 600–606.

27. Yue Wang, Yasumasa Okazaki, Lei Shi, Hiro Kohda, Minoru Tanaka, Kentaro Taki, Tomoki Nishioka, Tasuku Hirayama, Hideko Nagasawa, Yoriko Yamashita, Shinya Toyokuni*
“Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis”
Cancer Sci. 2016, 107, 250-257

26.Kozo Hattori, Kota Koike, Kensuke Okuda, Tasuku Hirayama, Masahiro Ebihara, Mei Takenaka, Hideko Nagasawa*
“Solution-Phase Synthesis and Biological Evaluation of Triostin A and its Analogues”
Org. Biomol. Chem. 2016,14, 2090-2111

<2015>

25. Masahiko Mori, Fumiya Ito, Lei Shi, Yue Wang, Chiharu Ishida, Yuka Hattori, Masato Niwa, Tasuku Hirayama, Hideko Nagasawa, Akira Iwase, Fumitaka Kikkawa, Shinya Toyokuni*
“Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron”
Redox Bioloby, 2015, 6, 578–586.

24. Takahiro Hikiji, Junpei Norisada, Yoko Hirata, Kensuke Okuda, Hideko Nagasawa, Yusuke Ishigaki, Gen Sobue, Kazutoshi Kiuchi, Kentaro Oh-hashi*
“A highly sensitive and quantitative assay of IRE1 activity using the small luciferase NanoLuc: evaluation of ALS-related genetic and pathological factors”
Biochem. Biophys. Res. Commun., 2015, 463, 881–887

23. 平山祐、丹羽正人、奥田健介、永澤秀子(総説)
【総説】「N-oxideの化学を利用した鉄(II)イオン蛍光プローブ分子の開発」
Chemical Biology, 2015, 8, 9–11.

22. Hitoshi Tsugawa, Hideki Mori, Juntaro Matsuzaki, Tatsuhiro Masaoka, Tasuku Hirayama, Hideko Nagasawa, Yasubumi Sakakibara, Makoto Suematsu, and Hidekazu Suzuki*
“Nordihydroguaiaretic Acid Disrupts the Antioxidant Ability of Helicobacter pylori through the Repression of SodB Activity In Vitro”
Biomedical Research International, 2015 doi:10.1155/2015/734548

21. Noriko Nozawa-Suzuki, Hideko Nagasawa, Ken Ohnishi, Ken-ichirou Morishige*
“The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer”
Biochemical and Biophysical Research Communications, 2015, 457, 706–711

20. Yuka Hattori, Takahiro Mukaide, Li Jiang, Tomomi Kotani, Hiroyuki Tsuda, Yukio Mano, Seiji Sumigawa, Tasuku Hirayama, Hideko Nagasawa, Fumitaka Kikkawa, and Shinya Toyokuni*
“Catalytic ferrous ion in amniotic fluid as a predictive marker of human maternal-fetal disorders”
Journal of Clinical Biochemistry and Nutrition, 2015, 56, 57-63

<2014>

19. 奥田健介、平山祐、永澤秀子
【総説】「低酸素・低栄養環境関連分子を標的とする創薬研究の現状」
放射線生物研究, 2015, 49(4), 341–357.

18. Masato Niwa, Tasuku Hirayama*, Kensuke Okuda Hideko Nagasawa*
“A new class of high-contrast Fe(II) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin”
Organic & Biomolecular Chemistry, 2014, 12, 6535-6746 (selected as front cover!)

cover2

17. Kosuke Narise, Kensuke Okuda, Yukihiro Enomoto, Tasuku Hirayama, Hideko Nagasawa*
“Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment”
Drug Design, Development and Therapy, 2014, 2014(8), 701–717

16. Tasuku Hirayama, Satoshi Ueda, Takahiro Okada, Norihiko Tsurue, Kensuke Okuda and Hideko Nagasawa*
“Facile One-Pot Synthesis of [1, 2, 3]Triazolo[1, 5-a]Pyridines from 2-Acylpyridines by Copper(II)-Catalyzed Oxidative N-N Bond Formation”
Chemistry – A European Journal, 2014, 20, 4156-4162

0-TOC

15. Takahiro Mukaide , Yuka Hattori , Nobuaki Misawa , Satomi Funahashi , Li Jiang , Tasuku Hirayama , Hideko Nagasawa and Shinya Toyokuni*
“Histological detection of catalytic ferrous iron with the selective turn-on fluorescent probe RhoNox-1 in a Fenton reaction-based rat renal carcinogenesis model”
Free Radical Research, 2014, 48, 990-995

<2013>

14. Mieko Tsuji,Satoshi Ueda , Tasuku Hirayama, Kensuke Okuda, Yoshiaki Sakaguchi, Aoi Isono, Hideko Nagasawa*
“FRET-based imaging of transbilayer movement of pepducin in living cells by novel intracellular bioreductively activatable fluorescent probes”
Organic & Biomolecular Chemistry, 2013, 11, 3030-3037

TOC-_OBC2010

13. Tasuku Hirayama, Kensuke Okuda, Hideko Nagasawa*
“A highly selective turn-on fluorescent probe for iron(II) to visualize labile iron in living cells”
Chemical Sciences, 2013, 4, 1250-1256

基本 RGB

<2012>

12. Kensuke, Okuda, Yasuyuki Okabe, Tetsuya Kadonosono, Takahiro Ueno, Bahaa Gamal Mohamed Youssif, Shinae Kondoh-Kizaka, Hideko Nagasawa
“2-Nitroimidazole-Tricarbocyanine Conjugate as a Near-Infrared Fluorescent Probe for in Vivo Imaging of Tumor Hypoxia.”
Bioconjugate Chemistry, 2012, 23, 324-329.

11. Hitoshi Miyakoshi, Seiji Miyahara, Tatsushi Yokogawa, Khoon Tee Chong, Junko Taguchi, Kanji Endoh, Wakako Yano, Takeshi Wakasa, Hiroyuki Ueno, Yayoi Takao, Makoto Nomura, Satoshi Shuto, Hideko Nagasawa, Masayoshi Fukuoka
“Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors.”
Journal of Medicinal Chemistry, 2012, 55, 2960-2969.

10. Bahaa Gamal Mohamed Youssif, Kensuke Okuda, Tetsuya Kadonosono, Ola Ibrahim Abdel Razek Salem, Alaa Arafat Mohamed Hayallah, Mostafa Ahmed Hussein, Shinae Kizaka-Kondoh, Hideko Nagasawa
“Development of a hypoxia-selective near-infrared fluorescent probe for non-invasive tumor imaging.”
Chemical Pharmaceutical Bulletin, 2012, 60, 402-407.

9. Tasuku Hirayama, Masayasu Taki, Kazushi Akaoka, Yukio Yamamoto
“Development of a dual functional luminescent sensor for zinc ion based on a peptidic architecture.”
Bioorganic & Medicinal Chemistry Letters,  2012, 22, 7410-7413.

<2011>

8. Hideko Nagasawa
“Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery:Drug Discovery for Targeting the Tumor Microenvironment”
Journal of Pharmacological Sciences, 2011, 115, 446-452.

7. Sadaaki Kimura, Shin-ichiro Masunaga, Tomohiro Harada, Yasuo Kawamura, Satoshi Ueda, Kensuke Okuda, Hideko Nagasawa
“Synthesis and evaluation of cyclic RGD-boron cluster conjugates to develop tumor-selective boron carriers for boron neutron capture therapy”
Bioorganic & Medicinal Chemistry, 2011, 19, 1721-1728.

6. Hisanori Hattori, Kensuke Okuda, Tetsuji Muirase, Yuki Shigetsura, Kousuke Narise, Gregg L. Semenza, Hideko Nagasawa
“Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis”
Bioorganic & Medicinal Chemistry, 2011, 19, 5392-5401.

<2010>

5. Satoshi Ueda, Takahiro Okada, Hideko Nagasawa
“Oxindole synthesis by palladium-catalysed aromatic C—H alkenylation”

Chemical Communications, 2010, 2462-2464.

<2009>

4. Kensuke Okuda, Takashi Hirota, David A Kingery, Hideko Nagasawa
“Synthesis of a fluorine-substituted puromycin derivative for Brønsted studies of ribosomal-catalyzed peptide bond formation.”
The Journal of Organic Chemistry, 2009, 74, 2609-2612.

3. Shinae Kizaka-Kondoh, Hideko Nagasawa
“Significance of nitroimidazole compounds and hypoxia-induceble factor-1 for imaging tumor hypoxia”
Cancer Science, 2009, 100, 1366-1373.

2. Satoshi Ueda, Hideko Nagasawa
“Copper-catalyzed synthesis of benzoxazoles via a regioselective C-H functionalization/C-O bond formation under an air atmosphere.”
The Journal of Organic Chemistry, 2009, 74, 4272-7277

1. Satoshi Ueda, Hideko Nagasawa
“Facile synthesis of 1,2,4-triazoles via a copper-catalyzed tandem addition-oxidative cyclization.”

Journal of the American Chemical Society, 2009, 131, 15080-15081