岐阜薬科大学 生体機能解析学大講座

一般論文

2003年以前(82報)

  1. Saito T., Fukuda T., Tajima S., Sukamoto T., Yamashita A., Kanazawa T., Morimoto Y., Shimohara K., Nishimura N., Yokota K., Ikegami A., Hara H. and Ito K. General pharmacology of 1-(2-ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate. Arzneim. -Forch./Drg Res., 38, 267-272, 1988.
  2. Ikegami A., Maeda A., Hara H., Sukamoto T., Yamashita A. and Ito K.Effect of trazodone (KB-831) and its metabolites on brain monoamines in rat.Folia Pharmacol. Japon 93, 145-154, 1989.
  3. Hara H. and Kogure K. Prevention of hippocampus neuronal damage in ischemic gerbils by a novel lipid peroxidation inhibitor (Quinazoline derivative). J. Pharmacol. Exp. Ther., 255, 906-913, 1990.
  4. Hara H., Kato H. and Kogure K. Protective effect of α-tocopherol on ischemic neuronal damage in the gerbil hippocampus. Brain Res., 510, 335-338, 1990.
  5. Hara H., Onodera H., Yoshidomi M., Matsuda Y. and Kogure K. Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil ahd rat. J. Cereb. Blood Flow & Metabol., 10, 646-653, 1990.
  6. Hara H., Onodera H., Kogure K. and Akaike N. The regional difference of neuronal susceptibility in the dentate gyrus to hypoxia. Neurosci. Lett., 115, 189-194, 1990.
  7. Hara H., Onodera H. and Kogure K. Protein kinase C activity in the gerbil hippocampus after transient forebrain ischemia: morphological and autoradiographic analysis using [3H]phorbol12,13-dibutyrate. Neurosci. Lett., 120, 120-123, 1990.
  8. Hara H., Ozaki A., Yoshidomi M. and Sukamoto T. Protective effect of KB-2796, a new calcium antagonist, on cerebral hypoxia and ischemia. Arch. Int. Pharmacodyn., 304, 206-218, 1990.
  9. Hara H., Nagasawa H. and Kogure K. Nimodipine prevents postischemic brain damage in the early phase of focal cerebral ischemia. Stroke, 21, 102-104, 1990.
  10. Hara H., Nagasawa H. and Kogure K. Nimodipine attenuates both ischemia-induced brain oedema and mortality in a rat novel transient middle cerebral artery occlusion model. Acta Neurochirugica., 51, 251-253, 1990.
  11. Hara H., Onodera H., Nagasawa H. and Kogure K. Effect of nimodipine on ischemia-induced brain edema and mortality in a novel transient middle cerebral artery occlusion model. Jpn. J. Pharmacol., 53, 247-253, 1990.
  12. Onodera H., Hara H., Kogure K., Fukunaga K., Ohta Y. and Miyamoto E. Ca2+/calmoduline-dependent protein kinase II immunoreactivity in the rat hippocampus after forebrain ischemia. Neurosci. Lett., 113, 134-138, 1990.
  13. Hori M., Iemura R., Hara H., Ozaki A., Sukamoto T. and Ohtaka H. Novel 4-phenoxy-2-(1-piperazinyl)quinazolines as potent anticonvulsive and antihypoxic agents. Chem. Pharm. Bull., 38, 681-687, 1990.
  14. Hori M., Iemura R., Hara H., Ozaki A., Sukamoto T. and Ohtaka H. Novel 4-substituted 2-piperazinylquinazolines as potent anticonvulsive and antihypoxic agents. Chem. Pharm. Bull., 38, 1286-1291, 1990.
  15. Hara H., Kato H., Araki T., Onodera H. and Kogure K. Involvement of lipid peroxidation and inhibitory mechanisms on ischemic neuronal damage in the gerbil hippocampus: Quantitative autoradiographic studies on second messenger and neurotransmitter systems. Neuroscience, 42, 159-169, 1991.
  16. Hara H., Onodera H., Kato H., Araki T. and Kogure K. Autoradiographic analysis of second messenger neurotransmitter system receptors in the gerbil hippocampus following transient forebrain ischemia. Brain Res., 545, 87-96, 1991.
  17. Hara H., Kogure K., Kato H., Ozaki A. and Sukamoto T. Amelioration of brain edema and neuronal damage from induced focal cerebral ischemia in the rat by a potential lipid peroxidation inhibitor. Eur. J. Pharmacol., 197, 75-82, 1991.
  18. Hara H., Onodera H., Kawagoe J. and Kogure K. Failure of basic fibroblast growth factor to prevent postischemic neuronal damage in the rat. Eur. J. Pharmacol., 209, 195-198, 1991.
  19. Kawagoe J., Hara H. and Kogure K. Distribution of protein kinase C activity in the hippocampus of the gerbil and rat: Autoradiographic analysis by [3H]phorbol 12,13-dibutyrate. J. Pharm. Pharmacol., 43, 758-761, 1991.
  20. Hori M., Iemura R., Hara H., Sukamoto T., Ito K. and Ohtaka H. Potential nootropic agents, 4-alkoxy-2-(1-piperazinyl)-quinazoline derivatives. Chem. Pharm. Bull., 39, 367-371, 1991.
  21. Kato H., Araki T., Hara H. and Kogure K. Sequential changes in muscarinic acetylcholine, adenosine A1 and calcium antagonist binding sites in the gerbil hippocampus following repeated brief ischemia. Brain Res., 553, 33-38, 1991.
  22. Yamasaki Y., Kogure K., Hara H., Ban H. and Akaike N. The possible involvement of tetrodotoxin-sensitive ion channels on ischemic neuronal damage in the rat hippocampus. Neurosci. Lett., 121, 251-254, 1991.
  23. Araki T., Kato H., Hara H. and Kogure T. Postischemic alteration of [3H]forskolin binding sites in selectively vulnerable areas: an autoradiographic study of gerbil brain. Neurosci. Lett., 125, 159-162, 1991.
  24. Kato H., Araki T., Hara H. and Kogure K. Autoradiographic analysis of second-messenger systems in the gerbil hippocampus following repeated brief ischemic insults. Brain Res. Bull., 27, 759-765, 1991.
  25. Hara H., Onodera H., Kato H. and Kogure K. Effects of aging on signal transmission and transduction systems in the gerbil brain: Morphological and autoradiographic study. Neuroscience, 46, 475-488, 1992.
  26. Hara H., Kato H., Onodera H., Kawagoe J. and Kogure K. Redional variations in particulate cyclic AMP dependent-protein kinase bindiing activity in the gerbil hippocampus following transient forebrain ischemia by [3H]cyclic AMP binding. Brain Res., 574, 26-32, 1992.
  27. Hara H., Sukamoto T., Abe K., Tatumi Y., Saito Y., Ohtaka H. and Tsukamoto G. Effects of baicalein and α-tocopherol on lipid peroxidation, free radical scavenging activity and 12-o-tetradecanoylphorbol acetate-induced ear edema. Eur. J. Pharmacol., 221, 193-198, 1992.
  28. Hara H., Onodera H. and Kogure K. Effects of hyperthermia on the effectiveness of MK-801 treatment in the gerbil hippocampus following transient forebrain ischemia. Brain Res. Bull., 29, 659-665, 1992.
  29. Ikegami A., Ozaki A., Hara H., Sukamoto T., Yamashita A. and Ito K. Neurochemical investigation of a new diphenylpiperazine calcium antagonist, KB-2796, on the central dopaminergic system in rats. Jpn. J. Pharmacol., 58, 399-405, 1992.
  30. Araki T., Kato H., Hara H. and Kogure K. Postischemic binding of [3H]phorbol 12,13-dibutyrate and [3H]inositol 1,4,5-trisphosphate in the gerbil brain: an autoradiographic study. Neuroscience, 46, 973-980, 1992.
  31. Yamamoto K., Nishimura N., Yoshidomi M., Hara H., Harada K., Iwamoto T., Harada Y., Ogata T. and Sukamoto T. General pharmacological studies on naftopidil (KT-611) and its main metabolites. The Clinical Report, 26, 229-246, 1992.
  32. Hara H., Harada K. and Sukamoto T. Chronological atrophy after transient middle cerebral artery occlusion in rats. Brain Res., 618, 251-260, 1993.
  33. Hara H., Yokota K., Shimazawa M. and Sukamoto T. Effect of KB-2796, a new diphenylpiperazine Ca2+ antagonist, on glutamate-induced neurotoxicity in rat hippocampal primary cell cultures. Jpn. J. Pharmacol., 61, 361-365, 1993.
  34. Akaike N., Ishibashi H., Hara H., Oyama Y. and Ueda T. Effect of KB-2796, a new diphenylpiperazine Ca2+ antagonist, on voltage-dependent Ca2+ currents and oxidative metabolism in dissociated mammalian CNS neurons. Brain Res., 619, 263-270, 1993.
  35. Morita T., Iwamoto T., Harada K., Hara H., Sukamoto T., Ito K. and Nurimoto S. Effects of 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl) piperazine dihydochloride (KB-2796) on cerebral circulation in dogs. Pharmacometrics, 45, 473-481, 1993.
  36. Yamashita A., Ozaki A., Ikegami A., Hayashi A., Hara H., Sukamoto T. and Ito K. Effects of a new diphenylpiperazine calcium antagonist, KB-2796, on cerebral ischemic neuronal damages in rats. Gen. Pharmacol. 24, 1473-1480, 1993.
  37. Morita T., Yamashita A., Morimoto Y., Saito T., Nishimura N., Yokota K., Hara H., Ikegami K., Harada A., Imamura A., Sukamoto T., Ito K. and Nurimoto S. General pharmacology of a novel Ca2+ antagonist, 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride (KB-2796). Pharmacometrics, 46, 243-260, 1993.
  38. Hara H., Tanaka K., Harada Y. and Sukamoto T. Sigma receptor-mediated effects of a new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric alkaline secreation in rats. J. Pharmacol. Exp. Ther., 269, 799-805, 1994.
  39. Harada Y., Hara H. and Sukamoto T. Characterization of specific (+)-[3H]N-allylnormetazocine and [3H]1,3-di(2-tolyl)guanidine binding sites in porcine gastric fundic mucosa. J. Pharmacol. Exp. Ther., 269, 905-910, 1994.
  40. Harada Y., Hara H. and Sukamotoo T. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur. J. Pharmacol., 256, 321-328, 1994.
  41. Harada Y., Hara. and Sukamoto T. Binding properties of KB-5492, a novel anti-ulcer agent, at sigma receptors in porcine gastric fundic mucosa. Eur. J. Pharmacol., 261, 91-96, 1994.
  42. Fujishima Y., Hara H., Shimazawa M., Yokota K. and Sukamoto T. The effects of novel Ca2+ channel blocker, KB-2796, on 5-HT-induced responses. Folia Pharmacol. Jpn., 104, 19-29, 1994.
  43. Watano T., Tanaka K., Hara H. and Sukamoto T. Analgesic effects of an antidepressant, trazodone hydrochloride (Reslin). J. Med. Pharmaceutical Sci., 32, 45-53, 1994.
  44. Kato H., Araki T., Hara H. and Kogure K. Regional changes in [3H]inositol 1,4,5-triphosphate binding in the gerbil brain following repeated sublethal ischemia. Brain Res. Bull., 33, 465-468, 1994.
  45. Morimoto Y., Oshima S., Hara H. and Sukamoto T. Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro. Jpn. J. Pharmacol., 64, 41-47, 1994.
  46. Morimoto Y., Shimohara K., Oshima S., Hara H. and Sukamoto T. Effects of KB-5492, a new anti-ulser agent with a selective affinity for the sigma-receptor, on aspirin-induced distribution of the rat gastric mucosal barrier. Jpn. J. Pharmacol., 64, 49-55, 1994.
  47. Morimoto Y., Shimohara K., Tanaka K., Hara H. and Sukamoto T. 4-Methoxyphenyl 4-(3,4,5-trimethoxybenzyl) -1-piperazineacetate monofumarate monohydrate (KB-5492), a new anti-ulcer agent with a selective affinity for the sigma receptor,prevents cysteamine-induced duodenal ulcers in rats by a mechanism different from that of cimetidine. Jpn. J. Pharmacol., 64, 221-224, 1994.
  48. Shimazawa M., Hara H., Watano T. and Sukamoto T. Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats. Br. J. Pharmacol., 115, 1359-1368, 1995.
  49. Watano T., Hara H., Yamashita A. and Sukamoto T. Effects of Dokkatsu-kakkon-to on the blood flow in the femoral skeletal muscle in anesthetized rats. J. Traditional Med., 12, 154-159, 1995.
  50. Hara H., Huang P. L., Panahian N., Fishman M. C. and Moskowitz M. A. Reduced brain edema and infarction volume in mice lacking the neuronal isoform of nitric oxide synthase after transient MCA occlusion. J. Cereb. Blood Flow & Metabol., 16, 605-611, 1996.
  51. Hara H., Waeber C., Huang P. L., Fujii M., Fishman M. C. and Moskowitz M. A. Brain distribution of nitric oxide synthase in neuronal or endothelial nitric oxide synthase mutant mice using [3H]L-NG-nitro-arginice autoradiography. Neuroscience, 75, 881-890, 1996.
  52. Shimazawa M. and Hara H. An experimental model of migraine with aura: cortical hypoperfusion following spreading depression in the awake and freely moving rat. Clin. Exp. Pharmacol. Physiol., 23, 890-892, 1996.
  53. Lo E., Hara H., Rogowska J., Trocha M., Pierce A. R., Huang P. L., Fishman M. V., Wolf G. L. and Moskowitz M. A. Temporal correlation mappping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression. Stroke, 27, 1381-1385, 1996.
  54. Yamaguchi T., Hara H., Harada Y., sakita Y. and Sukamoto T. The effects of naftopidil on blood pressure, heart rate and plasma norepinephrine level in freely moving rabbits. Jpn. Pharmacological.Ther., 24, 49-53, 1996.
  55. Meng W., Ma J., Ayata C., Hara H., Huang P. L., Fishman M. C. and Moskowitz M. A. Ach dilates pial arterioles in endothelial and neuronal NOS knockout mice by NO-dependent mechanisms. Am J. Physiol., 271, H1145-H1150, 1996.
  56. Hara H., Friedlander R. M., Gagliardini V., Ayata C., Fink K., Huang Z., Shimizu-Sasamata M., Yuan J. and Moskowitz M. A. Effects of inhibition of the ICE family proteases on ischemic and excitotoxic neuronal damage. Proc. Natl. Acd. Sci., U.S.A., 94, 2007-2012, 1997.
  57. Hara H., Ayata C., Huang P. L., Waeber C., Ayata G., Fujii M. and Moskowitz M. A. [3H]L-NG-Nitro-arginine binding after transient focal ischemia and NMDA-induced excitotoxicity in type I and type III nitric oxide synthase null mice. J. Cereb. Blood Flow & Metabol., 17, 515-526, 1997.
  58. Hara H., Ayata G., Huang P. L. and Moskowitz M. A. Alteration of protein kinase C activity binding after transient focal cerebral ischemia in mice using in vitro [3H]phorbol-12,13-dibutyrate binding autoradiography. Brain Res., 774, 69-76, 1997.
  59. Hara H., Fink K., Endres M., Friedlander R. M., Gagliardini V., Yuan J. and Moskowitz M. A. Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein. J. Cereb. Blood Flow & Metabol., 17, 370-375, 1997.
  60. Zaharachuck G., Hara H., Huang P. L., Fishman M. C., Moskowitz M. A., Jenkins B. G. and Rosen B. R. Neuronal nitric oxide synthase mutant mice show smaller infarcts and attenuated apparent diffusion coefficient changes in the peri-infarct zone during focal cerebral ischemia. Mag. Reson. Imag., 37, 170-175, 1997.
  61. Fujii M., Hara H., Meng W., Vonsattel J. P., Huang Z. and Moskowitz M. A. Strain-related differences in susceptibility to transient forebrain ischemia in SV-129 and C57black/6 mice. Stroke, 28, 1805-1811, 1997.
  62. Watano T., Hara H. and Sukamoto T. Inhibitory effect of lomerizine, a diphenylpiperazine Ca2+-channel blocker, on Ba2+ current through voltage-gated Ca2+ channels in PC12 calls. Jpn. J. Pharmacol., 75, 209-213, 1997.
  63. Friedlander R. M., Gagliardini V., Hara H., Fink K. B., Li W., MacDonald G., Fishman M. C., Greenberg A. H., Moskowitz M. A. and Yuan J. Expression of a dominant negative mutant of ICE in transgenic mice prevents neuronal cell death induced by trophic factotr withdrawal and ischemic brain injury. J. Exp. Med., 185, 933-940, 1997.
  64. Ayata C., Ayata G., Hara H., Mattews R. T., Beal M. F., Ferrante R. J., Endres M., Kim A., Christie R. H., Waeber C., Huang P. L., Hyman B. T. and Moskowitz M. A. Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice. J Neurosci., 17, 6908-6917, 1997.
  65. Ofuji K., Hara H., Sukamoto T. and Yamashita S. Effects of an antidiarrhoeica containing an extract from Geranium Herb on astringent action and short-circuit current asross jejunal mucosa. Folia Pharmacol. Japon, 111, 265-275, 1998.
  66. Bergeron L., Perez G. I., MacDonald G., Shi L., Sun Y., Jurisicova A., Varmuza S., Latham K. E., Flaws J. A., Salter J. C., Hara H., Moskowitz M. A., Li E., Greenberg A., Tilly J. L. and Yuan J. Defects in regulation of apoptosis in caspase-2-deficient mice. Genes and Development, 12, 1304-1314, 1998.
  67. Hara H., Shimazawa M., Hashimoto M. and Sukamoto T. Anti-migraine effects of lomerizine. Folia Pharmacol. Japon, 112, 138-142, 1998.
  68. Shimazawa M., Sugiyama T., Azuma I., Araie M., Iwakura Y., Watari M., Sakai T. and Hara H. Effects of lomerizine, a new Ca2+ channel blocker, on the microcirculation of optic nerve head in conscious rabbits using a laser speckle technique. Exp. Eye Res., 69, 185-193, 1999.
  69. Hara H., Shimazawa M., Sasaoka M., Yamada C., Iwakura Y., Sakai T., Maeda Y., YamaguchiT., Sukamoto T. and Hashimoto M. Selective effects of lomerizine, a novel diphenylmethylpiperazine Ca2+ channel blocker, on cerebral blood flow in rats and dogs. Clin. Exp. Pharmacol. Physiol., 26, 870-876, 1999.
  70. Toriu N., Akaike A., Yasuyoshi H., Zhang S., Kashii S., Honda Y., Shimazawa M. and Hara H. Lomerizine, Ca2+ channel blocker, reduces glutamate-induced neurotoxicity and ischemia/reperfusion damage in rrat retina. Exp. Eye Res., 70, 475-484, 2000.
  71. Shibata M., Hisahara S., Hara H., Yamawaki T., Fukuuchi Y., Yuan J., Okano H. and Miura M. Caspases determine the vulnerability of oligodendrocytes in the ischemic brain. J. Clin. Invest., 106, 643-653, 2000.
  72. Kang S., Wang S., Hara H., Peterson E. P., Namura S., Amin-Hanjani S., Huang Z., Srinivasan A., Tomaselli K. J., Thornberry N. A., Moskowitz M. A. and Yuan J. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J. Cell Biol., 149, 613-622, 2000.
  73. Toriu N., Sasaoka M., Shimazawa M., Sugiyama T. and Hara H. Effects of Lomerizine, a novel Ca2+ channel blocker, on the normal and endothelin-1-disturbed circulation in the optic nerve head of rabbits. J. Ocul. Pharmacol. Ther., 17,131-149, 2001.
  74. Ota T., Hara H. and Miyawaki N. Quantitative analysis of retinal ganglion cell damage following optic nerve axotomy in rats. Jpn. J. Ocular Pharmacol., 15, 29-30, 2001.
  75. Sugiyama T., Hara H., Oku H., Nakatsuji S., Okuno T., Sasaoka M., Ota T. and Ikeda T. Optic cup enlargement followed by reduced optic nerve head circulation after optic nerve stimulation. Invest. Ophthalmol. Vis. Sci., 42, 2843-2848, 2001.
  76. Kido N., Inatani M., Honjo M., Yoneda S., Hara H., Miyawaki N., Honda Y. and Tanihara H. Dual effects of interleukin-1β on N-methyl-D-aspartate-induced retinal neuronal death in rat eyes. Brain Res., 910, 153-162, 2001.
  77. Yoneda S., Tanihara H., Kido N., Honda Y., Goto W., Hara H. and Miyawaki N. Interleukin-1β mediates ischemic injury in the rat retina. Exp. Eye Res., 73, 661-667, 2001.
  78. Ota T., Hara H. and Miyawaki N. Brain-derived neurotrophic factor inhibits changes in soma-size of retinal ganglion cells following optic nerve axotomy in rats. J. Ocul. Pharmacol. Ther., 18, 241-249, 2002.
  79. Goto W., Ota T., Morikawa N., Otori Y., Hara H., Kawazu K., Miyawaki N. and Tano Y. Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina. Brain Res., 958, 10-19, 2002.
  80. Yoneda S., Tanaka E., Goto W., Ota T. and Hara H. Topiramate reduces excitotoxic and ischemic injury in the rat retina. Brain Res., 967, 257-266, 2003.
  81. Akaishi T., Shimazaki A., Matsugi T., Miyawaki N., Hara H. and Kuwayama Y. Effects of ocular hypotensive agents on the circadian rhythm in itraocular pressure in rabbits as measured by teremetry. Nippon Ganka Gakkai Zasshi, 107, 513-518, 2003.
  82. Nakajima T., Matsugi T., Goto W., Kageyama M., Mori N., Matsumura Y. and Hara H. New fluoroprostaglandin F derivatives with prostanoid FP-receptor agonistic acivity as potent ocular-hypotensive agents. Biol. Pharm. Bull., 26, 1691-1695, 2003.

2004年(14報)

  1. Ichikawa M., Okada Y., Hara H., Ishii K. and Araie M. Effects of topically bunazosin, an α1-adrenoceptor antagonist, on constrictions induced by phenylephline and ET-1 in rabbit retinal arteries. Invest. Ophthalmol. Vis. Sci., 45, 4041-4048, 2004.
  2. Taniguchi T., Shimazawa M. and Hara H. Alterrations in neurofilament light in optic nerve in rat kainate and monkey ocular hypertension models. Brain Res., 1013, 241-248, 2004.
  3. Yamamoto R., Yoneda S. and Hara H. Neuroprotective effects of β-secretase inhibitors against rat retinal ganglion cell death. Neurosci. Lett., 370, 61-64, 2004.
  4. Takagi Y., Nakajima T., Shimazaki A., Kageyama M., Matsugi T., Matsumura Y., Gabelt B. T., Kaufman P. L. and Hara H. Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp. Eye Res., 78, 767-776, 2004.
  5. Okada Y., Ichikawa M., Ishii K. and Hara H. Effects of topically instilled bunazosin hydrochloride and other ocular hypotensive drugs on endothelin-1-induced constriction in rabbit retinal arteries. Jpn. J. Ophthalmol., 48, 465-469, 2004.
  6. Akashi T., Takagi Y., Matsugi T., Ishida N., Hara H. and Kashiwagi K. Effects of bunazosin hydrochloride on ciliary muscle constriction and matrix metalloproteinase activities. J. Glaucoma, 13, 312-318, 2004.
  7. Goto W., Ichikawa M., Tanaka E., Hara H. and Araie M. Bunazosin hydrochloride reduces glutamate-induced neurotoxicity in rat primary retinal cultures. Brain Res., 1003, 130-137, 2004.
  8. Shimazaki A., Suhara H., Ichikawa M., Matsugi T., Konomi K., Takagi Y., Hara H., Rao P. O. and Epstein D. L. New ethacrynic acid derivatives as potent cytoskeletal modulators in trabecular meshwork cells. Biol. Pharm. Bull., 27, 846-850, 2004.
  9. Shimazaki A., Ichikawa M., Rao P. O., Kirihara T., Konomi K., Epstein D. L. and Hara H. Effects of the new ethacrynic acid derivative SA9000 on intraocular pressure in cats and monkeys. Biol. Pharm. Bull., 27, 1019-1024, 2004.
  10. Matsumura Y., Mori N., Nakano T., Sasakura H., Matsugi T., Hara H. and Morizawa Y. Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168: a novel 15-deoxy15,15,-difluoroprostaglandin F derivative. Tetrahedron Lett., 45, 1527-1529, 2004.
  11. Taniguchi T., Shimazawa M. and Hara H. Change in phosphorylated neurofilament heavy chain in the rat kainite-induced optic nerve damage. J. Eye 21, 1101-1104, 2004.
  12. Matsugi T., Takagi Y., Nakajima T., Goto W., Kageyama M., Mori N., Matsunuma Y. and Hara H. Prostanoid FP-receptor agonistic activities and ocular hypotensive effects of 15,15-difluoro prostaglandin F derivatives. Jpn. J. Ocular Pharmacol., 18, 74-76, 2004.
  13. Oku H., Goto W., Okuno T., Kobayashi T., Sugiyama T., Ota T., Yoneda S., Hara H. and Ikeda T. Effects of poly(ADP-ribose) polymerase inhibitor on NMDA-induced retinal injury. Curr. Eye Res., 29, 403-411, 2004.
  14. Oku H.,Goto W., Kobayashi T., Okuno T., Hirano M., Sugiyama T., Yoneda S., Hara H. and Ikeda T. Adenosine protects cultured retinal neurons agonist NMDA-induced cell death through A1 receptors. Curr. Eye Res., 29, 449-488, 2004.

2005年(11報)

  1. Yoneda S., Hara H., Hirata A., Fukushima M., Inomata Y. and Tanihara H. Vitreous fluid levels of β-amyloid(1-42) and Tau in patients with retinal diseases. Jpn. J. Ophthalmol., 49, 106-108, 2005.
  2. Morimoto N., Shimazawa M., Yamashita T., Nagai H. and Hara H. Minocycline inhibits oxidative stress and decreases in vitro and in vivo ischemic neuronal damage. Brain Res., 1044, 8-15, 2005.
  3. Yoneda S., Shimazawa M., Kato M., Nonoyama A., Torii Y., Nishino H., Sugimoto N., Kozaki S. and Hara H. Comparison of the therapeutic indexes of different molecular forms of botulinum toxin type A. Eur. J. Pharmacol., 508, 223-229, 2005.
  4. Shimazawa M., Miyake Y., Yamaguchi T., Yokota K., Sukamoto T. and Hara H. Effect of pamicogrel, a new antiplatelet drug, on the progression of sodium laurate-induced arterial occlusive in guinea pigs. Jpn. J. Thromb. Hemost., 16, 212-221, 2005.
  5. Sasaoka M., Hara H. and Nakamura K. Comparison between monkey and human visual fields using a personal computer system. Behavioral Brain Res., 161, 18-30, 2005.
  6. Shimazawa M., Chikamatsu S., Morimoto N., Mishima S., Nagai H. and Hara H. Neuroprotection by Brazilian green propolis in vitro and in vivo ishemic neuronal damage. eCAM, 2, 201-207, 2005.
  7. Taniguchi T., Shimazawa M., Araie M., Tomita G., Sasaoka M., Kitazawa Y. and Hara H. Optic disc topographic parameters measured in the normral cynomolgus monkey by confocal scanning laser tomography. Br. J. Ophthalmol., 89, 1058-1062, 2005.
  8. Shimazawa M., Yamashita T., Agarwal N. and Hara H. Neuroprotective effects minocycline against in vitro and in vivo retinal ganglion cell damage. Brain Res., 1053, 185-194, 2005.
  9. Akaishi T., Ishida N., Shimazaki A., Hara H. and Kuwayama Y. Continuous monitoring of circadian variations in intraocular pressure by telemetry system throughout 12 weeks’ treatment with timolol maleate in rabbits. J. Ocul. Pharmacol. Ther., 21, 436-444, 2005.
  10. Shimazawa M., Kondo K., Hara H., Nakashima M. and Umemura K. Sulfatides, L-and P-selectin ligands, exacerbate the intimal hyperplasia occurring after endothelial injury. Eur. J. Pharmacol., 520, 118-126, 2005.
  11. Shimazawa M., Watanabe S., Kondo K., Hara H.., Nakashima M. and Umemura K. Neutrophil accumulation promotes intimal hyperplasia after photochemically induced arterial injury in mice. Eur. J. Pharmacol., 520, 156-163, 2005.

2006年(13報)

  1. Tsuruma K., Nakagawa T., Morimoto N., Minami M., Hara H., Uehara T. and Nomura Y. Glucocorticoid modulatory element-binding protein 1 binds to initiator procaspases and inhibits ischemia-induced apoptosis and neuronal injury. J. Biol. Chem., 281, 11397-11404, 2006.
  2. Komine-Kobayashi M., Zhang N., Liu M., Tanaka R., Hara H., Osaka A., Mochizuki H., Mizuno Y. and Urabe T. Neuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of mice. J. Cereb. Blood Flow & Metabol., 26, 402-413, 2006.
  3. Sasaoka M., Taniguchi T., Shimazawa M., Ishida N., Shimazaki A. and Hara H. Intravitreal injection of endotheline-1 caused optic nerve damage following to ocular hypoperfusion in rabbits. Exp. Eye Res., 82, 427-440, 2006.
  4. Taniguchi T., Shimazawa M., Sasaoka M. and Hara H. Endothelin-1 impairs retrograde axonal transport and leads to axonal injury in rat optic nerve. Curr. Neurovasc. Res., 3, 81-88, 2006.
  5. Shimazawa M., Taniguchi T., Sasaoka M. and Hara H. Nerve fiber layer measurememt using scanning laser polarimetry with fixed corneal compensator in normal cycnomolgus monkey eyes. Ophthalmic Res., 38, 1-7, 2006.
  6. Shimazawa M., Tomita G., Taniguchi T., Sasaoka M., Hara H., Kitazawa Y. and Araie M. Morphometric evaluation of changes with time in optic disc structure and thickness of retinal nerve fibre layer in chronic ocular hypertensive monkeys. Exp. Eye Res., 82, 427-440, 2006.
  7. Inokuchi Y., Shimazawa M., Nakajima Y., Suemori S., Mishima S. and Hara H. Brazilian green propolis protects against retinal damage in vitro and in vivo. eCAM, 3, 71-77, 2006.
  8. Oida Y., Kitaichi K., Nakayama H., Ito Y., Fujimoto Y., Shimazawa M., Nagai H. and Hara H. Rifampicin attenuates the MPTP-induced neurotoxicity in mouse brain. Brain Res., 1082, 196-204, 2006.
  9. Hara H., Oh-hashi K., Yoneda S., Shimazawa M., Inatani M., Tanihara H. and Kiuchi K. Elevated neprilysin activity in vitreous of patients with proliferative diabetic retinopathy. Mol. Vision, 12, 977-982, 2006.
  10. Suemori S., Shimazawa M., Kawase K., Satoh M., Nagase H., Yamamoto T. and Hara H. Metallothionein, an endogeneous antioxidant, protects against retinal neuron damage in mice. Invest. Ophthalmol. Vis. Sci., 47, 3975-3982, 2006.
  11. Wakida K., Morimoto N., Shimazawa M., Hozumi I., Nagase H., Inuzuka T. and Hara H. Cilostazol reduces ischemic brain damage partly by inducing metallothionein-1 and -2. Brain Res., 1116, 187-193, 2006.
  12. Ito Y., Shimazawa M., Akao Y., Nakajima Y., Seki N., Nozawa Y. and Hara H. Lig-8, a bioactive lignophenol derivative from bamboo lignin, protects against neuronal damage in vitro and in vivo. J. Pharmacol. Sci., 102, 196-204, 2006.
  13. Shimazawa M. amd Hara H. Inhibitor of double stranded RNA-dependent proteinkinase protects against cell damage induced by ER stress. Neurosci. Lett., 409, 192-195, 2006.

2007年(9報)

  1. Nakajima Y., Shimazawa M., Mishima S. and Hara H. Water extract of propolis and its main constituents, caffeoylquinic acid derivatives, exert neuroprotective effects vis antioxidant actions. Life Sci., 80, 370-377, 2007.
  2. Chikaraishi Y., Shimazawa M. and Hara H. New quantitative analysis, using high-resolution images, of oxygen-induced retinal neovascularization in mice. Exp. Eye Res., 84, 529-536, 2007.
  3. Shimazawa M., Inokuchi Y., Ito Y., Murata H., Aihara M., Miura M., Araie M. and Hara H. Involvememt of ER stress in retinal cell death. Mol. Vision, 13, 578-587, 2007.
  4. Kondo S., Saito A., Hino S., Murakami T., Ogata M., Kanemoto S., Nara S., Yamashita A., Hara H. and Imaizumi K. BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of ER stress transducer. Mol. Cell. Biol., 27, 1716-1729, 2007.
  5. Shimazawa M., Ito Y., Inokuchi Y. and Hara H. Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage. Invest. Ophthalmol. Vis. Sci., 48, 3729-3736, 2007.
  6. Yamashita K., Kotani Y., Nakajima Y., Shimazawa M., Yoshimura S., Nakashima S., Iwama T. and Hara H. Fasudil, a Rho kinase(ROCK) inhibitor, protects against ischemic neuronai damage in vitro and in vivo by acting directly on neurons. Brain Res., 1154, 215-224, 2007.
  7. Morimoto N., Oida Y., Shimazawa M., Miura M., Kudo T., Imaizumi K. and Hara H. Involvement of endoplasmic reticulum stress after middle cerebral artery occlusion in mice. Neuroscience, 147, 957-967, 2007.
  8. Wakida K., Shimazawa M., Satoh M., Nagase H., Imaizumi T. and Hara H. Neuroprotective effect of erythropoietin, and role of metallothionei-1 and -2, in permanent focal cerebral ischemia. Neuroscience, 148, 105-114, 2007.
  9. Kotani Y., Morimoto N., Oida Y., Tamura Y., Tamura S., Inoue T., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Prevention of in vitro and in vivo acute ischemic neuronal damage by (2S)-1-(4-Amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4-fluorobenzyl) phenyl]-1-piperazinyl}-2-propanol dimethanesulfonate (SUN N8075), a novel neuroprotective agent with antioxidant properties. Neuroscience, 149, 779-788, 2007.

2008年(20報)

  1. Chikaraishi Y., Matsunaga N., Shimazawa M. and Hara H. Rifampicin inhibits the retinal neovascularization in vitro and in vivo. Exp. Eye Res., 86, 131-137, 2008.
  2. Oida Y., Shimazawa M., Imaizumi K. and Hara H. Involvement of endoplasmic reticulum stress in the neuronal death induced by transient forebrain ischemia in gerbil. Neuroscience, 151, 111-119, 2008.
  3. Kudo T., Kanemoto S., Hara H., Morimoto N., Morihara T., Kimura R., Tabira T., Imaizumi K and Takeda M. A molecular chaperone inducer protects neurons from ER stress. Cell Death and Differentiation, 15, 364-375, 2008.
  4. Matsunaga N., Shimazawa M., Otsubo K. and Hara H. Phosphatidylinositol inhibits vascular endothelial growth factor-A-induced migration of human umbilical vein endothelial cells. J. Pharmacol. Sci., 106, 128-135, 2008.
  5. Kotani Y., Nakajima Y., Hasegawa T., Satoh M., Nagase H., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Propofol exerts greater neuroprotection with disodium edetate than without it. J. Cereb. Blood Flow & Metabol., 28, 354-366, 2008.
  6. Hara H., Ise Y., Morimoto N., Shimazawa M., Ichihashi K., Ohyama M. and Iinuma M. Laxative effect of agarwood leaves and its mechanism. Biosci. Biotech. Biochem., 72, 335-345, 2008.
  7. Oyagi A., Oida Y., Hara H., Izuta H., Shimazawa M., Matsunaga N., Adachi T. and Hara H. Protective effects of SUN N8075, a novel agent with antioxidant properties, in in vitro and in vivo models of Parkinson’s disease. Brain Res., 1214, 169-176, 2008.
  8. Ito Y., Shimazawa M., Inokuchi Y., Fukumitsu H., Furukawa S., Araie M. and Hara H. Degenerative alterations in the visual pathway after NMDA-induced retinal damage in mice. Brain Res., 1212, 89-101, 2008.
  9. Yamamoto T., Shibata N., Takashima M., Nakamura S., Toru T., Matsunaga N. and Hara H. Enzymatic resolution and evaluation of enantiomers of cis-5′-hydroxythalidomide. Org. Biomol. Chem., 6, 1540-1543, 2008.
  10. Oida Y., Izuta H., Oyagi A., Shimazawa M., Kudo T., Imaizumi K. and Hara H. Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil. Brain Res., 1208, 217-224, 2008.
  11. Sasaoka M., Nakamura K., Shimazawa M., Ito Y., Araie M. and Hara H. Changes in visual fields and lateral geniculate nucleus in monkey laser-induced high intraocular pressure model. Exp. Eye Res., 86, 770-782, 2008.
  12. Matsunaga N., Chikaraishi Y., Izuta H., Ogata N., Shimazawa M., Matsumura M. and Hara H. Role of soluble vascular endothelial growth factor receptor-1 in the vitreous in proliferative diabetic retinopathy. Ophthalmology, 115, 1916-1922, 2008.
  13. Ito Y., Nakamura S., Tanaka H., Shimazawa M., Araie M. and Hara H. Memantine protects against secondary neuronal degeneration in lateral geniculate nucleus and superior colliculus after retinal damage in mice. CNS Neuroscience & Therapeutics, 14, 192-202, 2008.
  14. Nonaka Y., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Combination effects of normobaric hyperoxia and edaravone on focal cerebral ischemia-induced neuronal damage in mice. Neurosci. Lett., 441, 224-228, 2008.
  15. Nakajima Y., Inokuchi Y., Nishi M., Shimazawa M., Otsubo K. and Hara H. Coenzyme Q10 protects retinal cells against oxidative stress in vitro and in vivo. Brain Res., 1226, 226-233, 2008.
  16. Nakajima Y., Inokuchi Y., Shimazawa M., Otsubo K. Ishibashi T. and Hara H. Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in vitro and in vivo. J. Pharmacy & Pharmacology. 60, 1365-1374, 2008.
  17. Shimazawa M., Inokuchi Y., Okuno T., Nakajima Y., Sakaguchi G., Kato A., Oku H., Sugiyama T., Kudo T., Ikeda T., Takeda M. and Hara H. Reduced retinal function in amyloid precursor protein-over-expressing transgenic mice via attenuating glutamate-N- methyl-D-aspartate receptor signaling. J. Neurochem., 107, 279-290, 2008.
  18. Izuta H., Shimazawa M., Tazawa S., Araki Y., Mishima S. and Hara H. Protective effects of Chinese propolis and its component, chrysin against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells. J. Agricul. Food Chem., 56, 8944-8953, 2008.
  19. Uchibayashi R., Yokoyama Y., Nakajima Y., Matsunaga N., Shimazawa M. and Hara H. Antiangiogenic effects of Chinese medicines (Hachimijiogan and Kogikujiogan) on vascular endothelial growth factor-A-induced tube formation in human umbilical vein endothelial cells co-cultured with fibroblasts. J. Complement. Integr. Med., 5, 1, 20, 2008.
  20. Koumura A., Nonaka Y., Hyakkoku K., Oka T., Shimazawa M., Hozumi I., InuzukaT. and Hara H. A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice. Neuroscience, 157, 309-318, 2008.

2009年(27報)

  1. Inokuchi Y., Nakajima Y., Shimazawa M., Kurita T., Kubo M., Saito A., Sajiki H., Kudo T., Aihara M., Imaizumi K., Araie M. and Hara H. Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Invest. Ophthalmol. Vis. Sci., 50, 334-344, 2009.
  2. Izuta H., Chikaraishi Y., Shimazawa M., Mishima S. and Hara H. 10-Hydroxy-2-decenoic acid, a major fatty acid from Royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells. eCAM, 6, 489-494, 2009. http://ecam.oxfordjournals.org/cgi/content/abstract/6/4/489?etoc
  3. Inokuchi Y., Shimazawa M., Nakajima Y., Komuro I., Matsuda T., Baba A., Araie M., Kita S., Iwamoto T. and Hara H. A Na+/Ca2+ exchanger isoform, NCX1, involves in retinal cell death after N-Methyl-D-aspartate and ischemia-reperfusion. J. Neurosci. Res., 87, 906-917, 2009.
  4. Imamura K., Onoe H., Shimazawa M., Nozaki S., Wada Y., Kato K., Nakajima H., Mizuma H., Onoe K., Taniguchi T., Sasaoka M., Hara H., Tanaka S., Araie M. and Watanabe Y. Molecular imaging reveals unique degenerative changes in experimental glaucoma. NeuroReport, 20, 139-144, 2009.
  5. Matsunaga N., Imai S., Inokuchi Y., Shimazawa M., Yokota S., Araki Y. and Hara H. Bilberry and its main constituents have neuroprotective effects against retinal neuronal damage in vitro and in vivo. Molecular Nutrition and Food Research, 53, 869-877, 2009.
  6. Shimazawa M., Nakajima Y., Mashima Y. and Hara H. Docosahexaenoic acid (DHA) has neuroprotective effects against oxidative stress in retinal ganglion cells Brain Res., 1251, 269-275, 2009.
  7. Hyakkoku K., NakajimaY., Izuta H., Shimazawa M., Yamamoto T., Shibata N. and Hara H. Thalidomide protects against ischemic neuronal damage induced by focal cerebral ischemia in mice. Neuroscience, 159, 760-769, 2009.
  8. Nakajima Y., Shimazawa M., Otsubo K., Ishibashi T. and Hara H. Zeaxanthin, a retinal carotenoid, protects retinal cells against oxidative stress. Curr. Eye Res., 34, 311-318, 2009.
  9. Nakajima Y., Shimazawa M., Mishima S. and Hara H. Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis. Phytotherapy Research, 23, 1431-1438, 2009.
  10. Nonaka Y., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage. Neurosci. Lett., 452, 156-161, 2009.
  11. Nakajima Y., Tsuruma K., Shimazawa M., Mishima S. and Hara H. Comparison of bee products based on assays of antioxidant capacities. BMC Complement. Altern. Med., 9: 4, 2009. http://www.biomedcentral.com/1472-6882/9/4
  12. Inokuchi Y., Imai S., Nakajima Y., Shimazawa M. and Hara H. Edaravone, a free radical scavenger, protects against retinal damage in vitro and in vivo. J. Pharmacol. Exp. Ther., 329, 687-698, 2009.
  13. Hironaka K., Inokuchi Y., Tozuka Y., Shimazawa M., Hara H. and Takeuchi H. Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye. J. Control. Release, 136, 247-253, 2009.
  14. Yamamoto T., Shibata N., Sukeguchi D., Takashima M., Nakamura S., Toru T., Matsunaga N., Hara H., Tanaka M., Obata T. and Sasaki T.Synthesis, configurational stability and stereochemical biological evaluations of (S)- and (R)-5-hydroxythalidomides. Bioorg. Med. Chem. Lett., 19, 3973-3976, 2009.
  15. Tanaka H., Ito Y., Nakamura S., Shimazawa M. and Hara H. Involvement of brain-derived neurotrophic factor in time-dependent neurodegeneration in the murine superior colliculus after intravitreal injection of N-methyl-D-aspartate. Mol. Vision, 15, 662-669, 2009.
  16. Ito Y., Shimazawa M., Chen Y. N., Tsuruma K., Yamashita T., Araie M. and Hara H. Morphological changes in the visual pathway induced by experimental glaucoma in Japanese monkeys. Exp. Eye Res., 89, 246-255, 2009.
  17. Nonaka Y., Koumura A., Hyakkoku K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Combination treatment with normobaric hyperoxia and cilostazol protects mice against focal cerebral ischemia-induced neuronal damage better than each treatment alone. J. Pharmacol. Exp. Ther., 330, 13-22, 2009.
  18. Chikaraishi Y., Shimazawa M., Yokota K., Yoshino K. and Hara H. CB-12181, a new azasugar-based matrix metalloproteinase/tumor necrosis factor-α converting enzyme inhibitor, inhibits vascular endothelial growth factor-induced angiogenesis in vitro and retinal neovascularization in vivo. Current Neurovascular Research, 6, 140-147, 2009.
  19. Maruyama H., Sumitou Y., Sakamoto T., Araki Y. and Hara H. Antihypertensive effects of flavonoids isolated from Brazilian green propolis in spontaneously hypertensive rats. Biol. Pharm. Bull., 32, 1244-1250, 2009.
  20. Koumura A., Hamanaka J., Shimazawa M., Honda A., Tsuruma K., Uchida Y., Hozumi I., Satoh M., Inuzuka T. and Hara H. Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia. Brain Res., 1292, 148-154, 2009.
  21. Kakefuda K., Fujita Y., Oyagi A., Hyakkoku K., Kojima T., Umemura K., Tsuruma K., Shimazawa M., Ito M., Nozawa Y. and Hara H. Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection. Biochemical and Biophysical Research Communications, 387, 784-788, 2009.
  22. Ito Y., Yamada M., Tanaka H., Aida K., Tsuruma K., Shimazawa M., Hozumi I., Inuzuka T., Takahashi H. and Hara H. Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice. Neurobiology of Disease, 36, 470-476, 2009.
  23. Izuta H., Narahara Y., Shimazawa M., Mishima S., Kondo S. and Hara H. 1,1-Diphenyl-2-Picrylhydrazyl (DPPH) Radical Scavenging Activity of Bee Products and Their Constituents Determined by ESR Biol. Pharm. Bull., 32, 1947-1951, 2009.
  24. Koumura A., Kakefuda K., Honda A., Ito Y., Tsuruma K., Shimazawa M., Uchida Y., Hozumi I., Satoh M., Inuzuka T. and Hara H. Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors. Neurosci. Lett., 467, 11-14, 2009.
  25. Oyagi A., Oida Y., Kakefuda K., Shimazawa M., Shioda N., Moriguchi S., Kitaichi K., Nanba D., Yamaguchi K., Furuta Y., Fukunag K., Higashiyama S. and Hara H. Generation and characterization of conditional heparin-binding EGF-like growth factor knockout mice. PLoS ONE, 4(10) : e7461, 2009.
  26. Izuta H., Chikaraishi Y., Adachi T., Shimazawa M., Sugiyama T., Ikeda T., and Hara H. Extracellular SOD and VEGF are increased in vitreous body from proliferative diabetic retinopathy patients. Mol. Vision, 15, 2663-2672, 2009. http://www.molvis.org/molvis/v15/a283/
  27. Izuta H.,Shimazawa M., Tsuruma K., Araki Y., Mishima S. and Hara H. Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells. BMC Complementary and Alternative Medicine, 9: 45, 2009. http://www.biomedcentral.com/1472-6882/9/45

2010年(29報)

  1. Nakamura S., Chikaraishi Y., Tsuruma K., Shimazawa M. and Hara H. Ruboxistaurin, a PKCβ inhibitor, inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt. Exp. Eye Res., 90, 137-145, 2010.
  2. Matsunaga N., Chikaraishi Y., Shimazawa M., Yokota S. and Hara H. Vaccinium myrtillus(Bilberry) extracts reduce angiogenesis in vitro and in vivo. eCAM, 7, 47-56, 2010. http://ecam.oxfordjournals.org/cgi/content/full/7/1/47
  3. Shimazawa M., Suemori S., Inokuchi Y., Matsunaga N., Nakajima Y., Oka T., Yamamoto T. and Hara H. A novel calpain inhibitor, ((1S)-1-((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl)carbamic acid 5-methoxy-3-oxapentyl ester (SNJ-1945), reduces murine retinal cell death in vitro and in vivo. J. Pharmacol. Exp. Ther., 332, 380-387, 2010.
  4. Ito Y., Nakamura S., Tanaka H., Tsuruma K., Shimazawa M., Araie M. and Hara H. Lomerizine, Ca2+-channel blocker, protects against neuronal degeneration within the visual center of the brain after retinal damage in mice. CNS Neuroscience and Therapeutics, 16, 103-114, 2010.
  5. Matsunaga N., Tsuruma K., Shimazawa M., Yokota S. and Hara H. Inhibitory actions of Bilberry anthocyanidins on angiogenesis. Phytotherapy Research, 24, S42-S47, 2010.
  6. Chikaraishi Y., Izuta H., Shimazawa M., Mishima S. and Hara H. Angiostatic effects of Brazilian green propolis and its chemical constituents. Molecular Nutrition and Food Research, 54, 566-575, 2010.
  7. Hino S., Kondo S., Yoshinaga K., Saito A., Murakami T., Kanemoto S., Sekiya H., Chihara K., Aikawa Y., Hara H., Kudo T., Sekimoto T., Funamoto T., Chosa E. and Imaizumi K. Regulation of ER molecular chaperone prevents bone loss in a murine model for osteoporosis. J. Bone and Mineral Metabolism, 28, 131-138, 2010.
  8. Sato T., Oku H., Tsuruma K., Katsumura K., Shimazawa M., Hara H., Sugiyama T. and Ikeda T. Effect of Hypoxia on Susceptibility of RGC-5 Cells to Nitric Oxide. Invest. Ophthalmol. Vis. Sci., 51, 2575-258, 2010.
  9. Inokuchi Y.,† Hironaka K.,† Fujisawa T., Tozuka Y., Tsuruma K., Shimazawa M., Takeuchi H. and Hara H, † contributed equally Physicochemical properties affecting retinal delivery of nanoparticulate systems via eyedrop administration. Invest. Ophthalmol. Vis. Sci., 51,3162-3170, 2010.
  10. Izuta H., Matsunaga N., Shimazawa M., Sugiyama T., Ikeda T. and Hara H. Proliferative diabetic retinopathy and relations among antioxidant activity, oxidative stress, and VEGF in the vitreous body. Mol. Vision, 16, 130-136, 2010.
  11. Honda A., Komuro H., Hasegawa T., Seko Y., Shimada A., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y and Satoh M. Resistance of metallothionein-III null mice to cadmium-induced acute hepatotoxicity. The Journal of Toxicological Sciences, 35, 209-215, 2010.
  12. Honda A., Komuro H., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y and Satoh M. Microarray analysis of the liver in metallothionein-III null mice treated with cadmium. The Journal of Toxicological Sciences, 35, 271-273, 2010.
  13. Tsuruma K., Tanaka Y., Shimazawa M. and Hara H. Induction of amyloid precursor protein by the neurotoxic peptide, amyloid-beta 25-35, causes retinal ganglion cell death. Journal of Neurochemistry, 113, 1545-1554, 2010.
  14. Imai S., Inokuchi Y., Nakamura S., Tsuruma K., Shimazawa M. and Hara H. Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina. Eur. J. Pharmacol., 642, 77-85, 2010
  15. Kakino M., Izuta H., Ito T., Tsuruma K., Araki Y., Shimazawa M., Oyama M., Iinuma M. and Hara H. Agarwood induces laxative effects via acetylcholine receptors on loperamide-induced constipation in mice. Biosci. Biotech. Biochem., 74, 1550-1555, 2010
  16. Maruyama H., Sakamoto T., Araki Y. and Hara H. Anti-inflammatory effect of bee pollen ethanol extract from Cistus sp. of Spanish on carrageenan-induced rat hind paw edema. BMC Complementary and Alternative Medicine, 10:30, 2010.
  17. Shirai Y., Kozuki T., Kakefuda K., Moriguchi S., Oyagi A., Horie K., Shimazawa M., Fukunaga K., Takeda J., Saito N. and Hara H. Essential role of diacylglycerol kinase beta (DGKβ) in neurite spine formation, cognitive function, and memory. PLoS ONE, 5(7) : e11602, 2010
  18. Oyagi A., Ogawa K., Kakino M. and Hara H. Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice. BMC Complementary and Alternative Medicine, 10:45, 2010.
  19. Kawase K., Lin W., Aoyama Y., Yamamoto T., Shimazawa M. and Hara H. Effects of timolol-related ophthalmic solutions on cultured human conjunctival cells. Jpn. J. Ophthalmol., 54, 615-621, 2010.
  20. Oida Y., Hamanaka J., Hyakkoku K., Shimazawa M., Kudo T., Imaizumi K., Yasuda T. and Hara H. Post-treatment of a BiP inducer prevents cell death after middle cerebral artery occlusion in mice. Neurosci. Lett., 484, 43-46, 2010.
  21. Hyakkoku K., Hamanaka J.,Tsuruma K., Shimazawa M., Tanaka H., Uematsu S., Akira S., Inagaki N., Nagai H. and Hara H. Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia. Neuroscience, 171, 258-267, 2010.
  22. Imai S., Shimazawa M., Nakanishi T., Tsuruma K. and Hara H. Calpain inhibitor protects cells against light-induced retinal degeneration. J. Pharmacol. Exp. Ther., 335, 645-652, 2010.
  23. Honda A., Komuro H., Shimada A., Hasegawa T., Seko Y., Nagase H., Hozumi I., Inuzuka T., Hara H., Fujiwara Y. and Satoh M. Attenuation of cadmium-induced testicular injury in metallothionein-III null mice. Life Sciences, 87, 545-550, 2010.
  24. Kakefuda K,, Oyagi A., Ishisaka M., Tsuruma K., Shimazawa M., Yokota K., Shirai Y., Horie K., Saito N., Takeda J. and Hara H. Diacylglycerol kinase β knockout mice exhibit lithium-sensitive behavioral abnormalities. PLoS ONE, 5(10) : e13447, 2010.
  25. Ishiguro M., Mishiro K., Fujiwara Y., Chen H., Izuta H., Tsuruma K., Shimazawa M., Yoshimura S., Satoh M., Iwama T.and Hara H. Phosphodiesterase-III inhibitor prevents hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tissue plasminogen activator. PLoS ONE, 5(12) : e15178, 2010.
  26. Shimazawa M., Tanaka H., Ito Y., Morimoto N., Tsuruma K., Kadokura M., Tamura S., Inoue Y., Yamada M., Takahashi H., Warita H., Aoki M. and Hara H. An inducer of VGF protects cells from ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS. PLoS ONE, 5(12) : e15307, 2010.
  27. Kakino M., Tazawa S., Maruyama H., Tsuruma K., Araki Y., Shimazawa M. and Hara H. Laxative effects of agarwood on low-fiber diet-induced constipation in rats. BMC Complementary and Alternative Medicine, 10: 68, 2010.
  28. Hyakkoku K., Hamanaka J., Tsuruma K., Shimazawa M. and Hara H. Proteomic approach with LCMS-IT-TOF identified an increase of Rab33B after transient focal cerebral ischemia in mice. Experimental & Translational Stroke Medicine, 2:29, 2010.
  29. Hayashi E., Kuratani K., Kinoshita M. and Hara H. Pharmacologically distinctive behaviors other than burying marbles during the marble burying test in mice. Pharmacology, 86, 293-296, 2010.

2011年(26報)

  1. Yamauchi M., Tsuruma K., Imai S., Nakanishi T., Umigai N., Shimazawa M. and Hara H. Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity. Eur. J. Pharmacol., 650, 110-119, 2011.
  2. Akane M., Shimazawa M., Inokuchi Y., Tsuruma K.and Hara H. SUN N8075, a novel radical scavenger, protects against retinal cell death in mice. Neurosci. Lett., 488, 87-91, 2011.
  3. Tanaka H., Shimazaki H., Kimura M., Izuta H., Tsuruma K., Shimazawa M. and Hara H. Apoptosis-inducing factor and cyclophilin a cotranslocate to the motor neuronal nuclei in amyotrophic lateral sclerosis model mice. CNS Neuroscience and Therapeutics, 17, 294-304, 2011.
  4. Nishioka Y., Oyagi A., Tsuruma K., Shimazawa M., Ishibashi T. and Hara H. The antianxiety-like effect of astaxanthin extracted from Paracoccus carotinifaciens. BioFactors, 37, 25-30, 2011.
  5. Ishisaka M., Kudo T., Shimazawa M., Kakefuda K., Oyagi A., Hyakkoku K., Tsuruma K. and Hara H. Restraint-induced expression of endoplasmic reticulum stress-related genes in the mouse brain. Pharmacology & Pharmacy, 2, 10-16, 2011.
  6. Tanaka J., Nakanishi T., Ogawa K., Tsuruma K., Shimazawa M., Shimoda H. and Hara H. Purple rice extract and anthocyanidins of the constituents protect light-induced retinal damage in vitro and in vivo. Journal of Agricultural and Food Chemistry, 59, 528-536, 2011.
  7. Ito Y., Shimazawa M., Inokuchi Y., Yamanaka H., Tsuruma K., Imamura K., Onoe H., Watanabe Y., Aihara M., Araie M. and Hara H. Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model. European Journal of Neuroscience, 33, 843-855, 2011.
  8. Nakamura S., Hayashi K., Takizawa H., Murase T., Tsuruma K., Shimazawa M., Kakuta H., Nagasawa H. and Hara H. An Arylidene-Thiazolidinedione Derivative, GPU-4, without PPARγ Activation, Reduces Retinal Neovascularization. Current Neurovascular Research, 8, 25-34, 2011.
  9. Ogawa K., Oyagi A., Tanaka J., Kobayashi S. and Hara H. The protective effect and action mechanism of Vaccinium myrtillus L. on gastric ulcer in mice. Phytotherapy Research, 25, 1160-1165, 2011.
  10. Hayashi E., Shimamura M., Kuratani K., Kinoshita M. and Hara H. Automated experimental system capturing three behavioral components during murine forced swim test. Life Sciences, 88, 411-417, 2011.
  11. Nakamura S., Morimoto N., Tsuruma K., Izuta H., Yasuda Y., Kato N., Ikeda T., Shimazawa M. and Hara H. Tissue kallikrein inhibits retinal neovascularization via the cleavage of vascular endothelial growth factor-165. Arteriosclerosis, Thrombosis, and Vascular Biology, 31, 1041-1048, 2011.
  12. Hironaka K., Inokuchi Y., Fujisawa T., Shimazaki H., Akane M., Tozuka Y., Tsuruma K., Shimazawa M., Hara H. and Takeuchi H. Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage. European Journal of Pharmaceutics and Biopharmaceutics, 79, 119-125, 2011.
  13. Hironaka K., Fujisawa T., Sasaki H., Tozuka Y., Tsuruma K., Shimazawa M., Hara H. and Takeuchi H. Fluorescence investigation of the retinal delivery of hydrophilic compounds via liposomal eyedrops. Biological and Pharmaceutical Bulletin, 34, 894-897, 2011.
  14. Ishiguro M., Suzuki Y., Mishiro K., Kakino M., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Blockade of phosphodiesterase-III protects against oxygen-glucose deprivation in endothelial cells by upregulation of VE-cadherin. Current Neurovascular Research, 8, 86-94, 2011.
  15. Oyagi A., Morimoto N., Hamanaka J., Ishiguro M., Tsuruma K., Shimazawa M. and Hara H. Forebrain specific heparin-binding epidermal growth factor-like growth factor knockout mice show exacerbated ischemia and reperfusion injury. Neuroscience, 185, 116-124, 2011.
  16. Uchibayashi R., Tsuruma K., Inokuchi Y., Shimazawa M. and Hara H. Involvement of Bid and caspase-2 in endoplasmic reticulum stress- and oxidative stress-induced retinal ganglion cell death. J. Neurosci. Res., 89, 1783-1794, 2011.
  17. Adachi T., Yasuda H., Nakamura S., Kamiya T., Hara H., Hara H. and Ikeda T. Endoplasmic reticulum stress induces retinal endothelial permeability of extracellular-superoxide dismutase. Free Radical Research, 45, 1083-1092, 2011.
  18. Numajiri N., Takasawa K., Nishiya T., Tanaka H., Ohno K., Hayakawa W., Asada M., Matsuda H., Azumi K., Kamata H., Nakamura T., Hara H., Minami M., Lipton S. A. and Uehara T. On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN). Proceedings of the National Academy of Sciences USA, 108, 10349-10354, 2011.
  19. Ishisaka M., Kakefuda K., Yamauchi M., Tsuruma K., Shimazawa M., Tsuruta A. and Hara H. Luteolin shows an antidepressant-like effect via supressing endoplasmic reticulum stress. Biol. Pharm. Bull., 34, 1481-1486, 2011.
  20. Yoshikawa T., Ogata N., Izuta H., Shimazawa M., Hara H. and Takahashi K. Increased expression of tight junctions in APRE19 cells under endoplasmic reticulum stress. Current Eye Research, 36, 1153-1163, 2011.
  21. Shimazaki H., Hironaka K., Fujisawa T., Tsuruma K., Tozuka Y., Shimazawa M., Takeuchi H. and Hara H. Edaravone-loaded liposome eye drops protect against light-induced retinal damage in mice. Invest. Ophthalmol. Vis. Sci., 52, 7289-7297, 2011.
  22. Oyagi A., Moriguchi S., Nitta A., Murata K., Oida Y., Tsuruma K., Shimazawa M., Fukunaga K. and Hara H. Heparin-binding EGF-like growth factor is required for synaptic plasticity and memory formation. Brain Res., 1419, 97-104, 2011.
  23. Hayashi E., Kobayashi T., Shiroshita Y., Kuratani K., Kinoshita M. and Hara H. An automated evaluation system for analyzing antinociceptive effects on intracolonic capsaicin-induced visceral pain-related licking behavior in mice. J. Pharmacol. Toxicol. Methods., 64, 119-123, 2011.
  24. Tsuruma K., Tanaka Y., Shimazawa M., Mashima Y. and Hara H. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels. Molecular Vision, 17, 3556-3565, 2011.
  25. Ogishima H., Nakamura S., Nakanishi T., Imai S., Kakino M., Ishizuka F., Tsuruma K., Shimazawa M. and Hara H. Ligation of the pterygopalatine and external carotid arteries induces ischemic damage in the murine retina. Invest. Ophthalmol. Vis. Sci., 52, 9710-9720, 2011.
  26. Koumura A., Hamanaka J., Kawasaki K., Tsuruma K., Shimazawa M., Hozumi I., Inuzuka T. and Hara H. Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion. J. Pharmacol. Exp. Ther., 338, 337-344, 2011.

2012年(27報)

  1. Tanaka J., Nakamura S., Tsuruma K., Shimazawa M., Shimoda H. and Hara H. Purple rice (Oryza sativa L.) extract and its constituents inhibit VEGF-induced angiogenesis. Phytotherapy Research, 26, 214-222, 2012.
  2. Ito Y., Shimazawa M., Tsuruma K., Mayama C., Ishii K., Onoe H., Aihara M., Araie M. and Hara H. Induction of amyloid-β1-42 in the retina and optic nerve head of chronic ocular hypertensive monkeys. Molecular Vision, 18, 2647-2657, 2012.
  3. Murata K., Oyagi A., Takahira D., Tsuruma K., Shimazawa M., Ishibashi T., Hara H. Protective effects of astaxanthin from Paracoccus carotinifaciens on murine gastric ulcer models. Phytotherapy Research, 26, 1126-1132, 2012.
  4. Ito T., Kakino M., Tazawa S., Watarai T., Oyama M., Maruyama H., Araki Y., Hara H. and Iinuma M. Quantification of polyphenols and pharmacological analysis of water and ethanol-based extracts of cultivated agarwood leaves. Journal of Nutritional Science and Vitaminology, 58, 136-142, 2012.
  5. Shimazawa M., Ito Y., Inokuchi Y., Yamanaka H., Nakanishi T., Hayashi T., Ji B., Higuchi M., Suhara T., Imamura K., Araie M., Watanabe Y., Onoe H. and Hara H. An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: In vivo positron emission tomography imaging of glial activation. PLoS ONE, 7(1), e30526, 2012.
  6. Mishiro K., Ishiguro M., Suzuki Y., Tsuruma K., Shimazawa M. and Hara H. A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice. Neuroscience, 205, 39-48, 2012.
  7. Tsuruma K., Yamauchi M., Inokuchi Y., Sugitani S., Shimazawa M. and Hara H. Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice. Journal of Pharmacological Sciences, 118, 351-362, 2011.
  8. Tsuruma K., Shimazaki H., Nakashima K., Yamauchi M., Sugitani S., Shimazawa M., Iinuma M. and Hara H. Annatto prevents retinal degeneration induced by endoplasmic reticulum stress in vitro and in vivo. Molecular Nutrition & Food Research, 56, 713-724, 2012.
  9. Nakamura S., Imai S., Ogishima H., Tsuruma K., Shimazawa M. and Hara H. Morphological and functional changes in the retina after chronic oxygen-induced retinopathy. PLoS ONE, 7(2), e32167, 2012.
  10. Hong S., Hara H., Shimazawa M., Hyakkoku K., Kim C. Y., and Seong G. J. Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic artery. Brazilian Journal of Medical and Biological Research, 45, 212-215, 2012.
  11. Umigai N., Tanaka J., Tsuruma K., Shimazawa M. and Hara H. Crocetin, a carotenoid derivative, inhibits VEGF-induced angiogenesis via suppression of p38 phosphorylation. Current Neurovascular Research, 9, 102-109, 2012.
  12. Shimazawa M., Miwa A., Ito Y., Tsuruma K., Aihara M. and Hara H. Involvement of endoplasmic reticulum stress in optic nerve degeneration following N-methyl-D-aspartate-induced retinal damage in mice. Journal of Neuroscience Research, 90, 1960-1969, 2012.
  13. Kakino M., Sugiyama T., Kunieda H., Tazawa S., Maruyama H., Tsuruma K., Araki Y., Shimazawa M., Ichihara K., Mori H. and Hara H. Agarwood (Aquilaria crassna) extracts decrease high-protein high-fat diet-induced intestinal putrefaction toxins in mice. Pharmaceutica Analytica Acta, 3:152, 2012.
  14. Nakamura S., Tsuruma K., Shimazawa M. and Hara H. Candesartan, an angiotensin II type 1 receptor antagonist, inhibits pathological retinal neovascularization by downregulating VEGF receptor-2 expression. European Journal of Pharmacology, 685, 8-14, 2012.
  15. Ishisaka M., Kakefuda K., Oyagi A., Ono Y., Tsuruma K., Shimazawa M., Kitaichi K. and Hara H. Diacylglycerol kinase β knockout mice exhibit attention-deficit behavior and an abnormal response on methylphenidate-induced hyperactivity. PLoS ONE, 7(5), e37058, 2012.
  16. Egashira Y., Sugitani S., Suzuki Y., Mishiro K., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. The conditioned medium of murine and human adipose-derived stem cells exerts neuroprotective effects against experimental stroke model. Brain Research, 1461, 87-95, 2012.
  17. Kasai H., Ishisaka M., Shirasawa E. and Hara H. A three-dimensional collagen gel contraction monitoring system that uses a porcine trabecular meshwork for screening of anti-intraocular pressure agents. Pharmaceutica Analytica Acta, 3:154, 2012.
  18. Ishiguro M., Kawasaki K., Suzuki Y., Ishizuka F., Mishiro K., Egashira Y., Ikegaki I., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue prasminogen activator. Neuroscience, 220, 302-312, 2012.
  19. Ito T., Kakino M., Tazawa S., Oyama M., Maruyama H., Araki Y., Hara H. and Iinuma M. Identification of phenolic compounds in Aquilaria crassna leaves via liquid chromatography-electrospray ionization mass spectroscopy. Food Science and Technology Research, 18, 259-262, 2012.
  20. Ohno Y., Nakanishi T., Umigai N., Tsuruma K., Shimazawa M. and Hara H. Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice. E uropean Journal of Pharmacology, 690, 84-89, 2012.
  21. Tanaka H., Shimazawa M., Kimura M., Takata M., Tsuruma K., Yamada M., Takahashi H., Hozumi I., Niwa J., Iguchi Y., Nikawa T., Sobue G., Inuzuka T. and Hara H. The potential of GPNMB as novel neuroprotective factor in amyotrophic lateral sclerosis. Scientific Reports, 2: 573, 2012.
  22. Tsuruma K., Nishimura Y., Kishi S., Shimazawa M., Tanaka T. and Hara H. SEMA4A mutations lead to susceptibility to light irradiation, oxidative stress, and ER stress in retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci., 53, 6729-6737, 2012.
  23. Ono Y., Shimazawa M., Ishisaka M., Oyagi A., Tsuruma K. and Hara H. Imipramine protects mouse hippocampus against tunicamycin-induced cell death. European Journal of Pharmacology, 696, 83-88, 2012.
  24. Kakino M., Izuta H., Tsuruma K., Araki Y., Shimazawa M., Ichihara K. and Hara H. Laxative effects and mechanism of action of Brazilian green propolis. BMC Complementary and Alternative Medicine, 12:192, 2012.
  25. Suzuki Y., Hattori K., Hamanaka J., Murase T., Egashira Y., Mishiro K., Ishiguro M., Tsuruma K., Hirose Y., Tanaka H., Yoshimura S., Shimazawa M., Inagaki N., Nagasawa H., Iwama T. and Hara H. Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia. Scientific Reports, 2: 896, 2012.
  26. Morimoto N., Kita S., Shimazawa M., Namimatsu H., Tsuruma K., Hayakawa K., Mishima K., Egashira N., Iyoda T., Horie I., Gotoh Y., Iwasaki K., Fujiwara M., Matsuda T., Baba A., Komuro I., Horie K., Takeda J., Iwamoto T. and Hara H. Preferential involvement of Na+/Ca2+ exchanger type-1 in the brain damage caused by transient focal cerebral ischemia in mice. Biochemical and Biophysical Research Communications, 429, 186-190, 2012.
  27. Tsuruma K., Shimazaki H., Ohno Y., Inoue Y., Honda A., Imai S., Lee J., Shimazawa M., Satoh M. and Hara H. Metallothionein-III deficiency exacerbates light-induced retinal degeneration. Invest. Ophthalmol. Vis. Sci., 53, 7896-7903, 2012.

2013年(26報)

  1. Mishiro K., Ishiguro M., Suzuki Y., Tsuruma K., Shimazawa M. and Hara H. Tissue plasminogen activator prevents restoration of tight junction proteins through upregulation of angiopoietin-2. Current Neurovascular Research, 10, 39-48, 2013.
  2. Tanaka J., Nakanishi T., Shimoda H., Nakamura S., Tsuruma K., Shimazawa M., Matsuda H., Yoshikawa M. and Hara H. Purple rice extract and its constituents suppress endoplasmic reticulum stress-induced retinal damage in vitro and in vivo. Life Sciences, 92, 17-25, 2013.
  3. Nakanishi T., Shimazawa M., Sugitani S., Kudo T., Imai S., Inokuchi Y., Tsuruma K. and Hara H. Role of endoplasmic reticulum stress in light-induced photoreceptor degeneration in mice. Journal of Neurochemistry, 125, 111-124, 2013.
  4. Kasai, H., Imamura T., Tsuruma K., Takahashi Y., Kurasawa T., Hirata H., Shimazawa M. and Hara H. Effects of roscovitine, a cell cycling-dependent kinase inhibitor, on intraocular pressure of rabbit and retinal ganglion cell damage. Neuroscience Letters, 535, 95-99, 2013.
  5. Hayashi T., Shimazawa M., Watabe H., Ose T., Inokuchi Y., Ito Y., Yamanaka H., Urayama S., Watanabe Y., Hara H. and Onoe H. Kinetics of neurodegeneration based on a risk-related biomarker in animal model of glaucoma. Molecular Neurodegeneration, 8:4, 2013.
  6. Tanaka J., Kadekaru T., Ogawa K., Hitoe S., Shimoda H. and Hara H. Maqui berry (Aristotelia chilensis) and the constituent delphinidin glycoside inhibit photoreceptor cell death induced by visible light. Food Chemistry, 139, 129-137, 2013.
  7. Takano N., Tsuruma K., Ohno Y., Shimazawa M. and Hara H. Bimatoprost protects retinal neuronal damage via Akt pathway. European Journal of Pharmacology, 702, 56-61, 2013.
  8. Ishizuka F., Shimazawa M., Umigai N., Ogishima H., Nakamura S., Tsuruma K. and Hara H. Crocetin, a carotenoid derivative, inhibits retinal ischemic damage in mice. European Journal of Pharmacology, 703, 1-10, 2013.
  9. Tanaka H., Shimazawa M., Takata M., Kaneko H., Tsuruma K., Ikeda T., Warita H., Aoki M., Yamada M., Takahashi H., Hozumi I., Minatsu H., Inuzuka T. and Hara H. ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis. Journal of Neurology, 260, 1782-1797, 2013.
  10. Nakamura S.#, Takizawa H.#, Shimazawa M.#, Hashimoto Y., Sugitani S., Tsuruma K. and Hara H. #: Contributed equally Mild endoplasmic reticulum stress promotes retinal neovascularization via induction of BiP/GRP78. PloS ONE, 8(3), e60517, 2013.
  11. Ishisaka M., Tsuruma K., Shimazawa M., Shirai M., Saito N. and Hara H. Increased seizure susceptibility in a mouse with diacylglycerol kinase β deficiency. Neuroscience & Medicine, 4, 117-122, 2013.
  12. Shimazawa M., Nakamura S., Miwa M., Tsuruma K., Aihara M., Nakamura K. and Hara H. Establishment of the ocular hypertension model using the common marmoset. Experimental Eye Research, 111, 1-8, 2013.
  13. Ono Y., Tanaka H., Tsuruma K., Shimazawa M. and Hara H. A Sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells. Biochemical and Biophysical Research Communications, 434, 904-909, 2013.
  14. Inoue Y., Tsuruma K., Nakanishi T., Oyagi A., Ohno Y., Otsuka T., Shimazawa M. and Hara H. Role of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in light-induced photoreceptor degeneration in mouse retina. Invest. Ophthalmol. Vis. Sci., 54, 3815-3829, 2013.
  15. Ohno Y., Makita S., Shimazawa M., Tsuruma K., Yasuno Y. and Hara H. Thickness mapping of the inner retina by spectral-domain optical coherence tomography in an N-methyl-D-aspartate-induced retinal damage model. Experimental Eye Research, 113, 19-25, 2013.
  16. Kitashoji A., Egashira Y., Mishiro K., Suzuki Y., Ito H., Tsuruma K., Shimazawa M. and Hara H. Cilostazol ameliorates warfarin-induced hemorrhagic transformation following cerebral ischemia in mice. Stroke, 44, 2862-2868, 2013.
  17. Kasai H., Aoyama Y., Kurasawa T., Imamura T., Tsuruma K., Hara H., Hirata H. and Yamamoto T. Comparison of efficacy and safety evaluation of latanoprost formulations with and without benzalkonium chloride. Pharmacology & Pharmacy, 4, 377-384, 2013.
  18. Takata M., Tanaka H., Kimura M., Nagahara Y., Tanaka K., Kawasaki K., Seto M., Tsuruma K., Shimazawa M. and Hara H. Fasudil, a rho kinase inhibitor, limits motor neuron loss in experimental amyotrophic lateral sclerosis models. British Journal of Pharmacology, 170, 341-351, 2013.
  19. Ishizuka F.#, Shimazawa M.#, Inoue Y., Nakano Y., Ogishima H., Nakamura S., Tsuruma K., Tanaka H., Inagaki N. and Hara H. #: Contributed equally Toll-like receptor 4 mediates retinal ischemia/reperfusion injury through nuclear factor-kappa B and spleen tyrosine kinase activation. Invest. Ophthalmol. Vis. Sci., 54, 5807-5816, 2013.
  20. Ishizuka F.#, Shimazawa M.#, Egashira Y., Ogishima H., Nakamura S., Tsuruma K. and Hara H. #: Contributed equally Cilostazol prevents retinal ischemic damage partly via inhibition of tumor necrosis factor-α-induced nuclear factor-kappa B/activator protein-1 signaling pathway. Pharmacology Research & Perspectives, 1, e00006, 2013.
  21. Egashira Y., Suzuki Y., Azuma Y., Takagi T., Mishiro K., Sugitani S., Tsuruma K., Shimazawa M., Yoshimura S., Kashimata M., Iwama T. and Hara H. The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment. J ournal of Neuroinflammation, 10: 105, 2013.
  22. Sugitani S., Tsuruma K., Ohno Y., Kuse Y., Yamauchi M., Egashira Y., Yoshimura S., Shimazawa M., Iwama T. and Hara H. The potential neuroprotective effect of human adipose stem cells conditioned medium against light-induced retinal damage. Experimental Eye Research, 116, 254-264, 2013.
  23. Otsuka T., Shimazawa M., Nakanishi T., Ohno Y., Inoue Y., Tsuruma K., Ishibashi T. and Hara H. The protective effects of a dietary carotenoid, astaxanthin, on light-induced retinal damage. Journal of Pharmacological Sciences, 123, 209-218, 2013.
  24. Ogawa K., Tsuruma K., Tanaka J., Kakino M., Kobayashi S., Shimazawa M. and Hara H. The protective effects of bilberry and lingonberry extracts against UV light-induced retinal photoreceptor cell damage in vitro. Journal of Agricultural and Food Chemistry, 61, 10345-10353, 2013.
  25. Suzuki Y., Nakano Y., Mishiro K., Takagi T., Tsuruma K., Nakamura M., Yoshimura S., Shimazawa M. and Hara H. Involvements of Mincle and Syk on the changes in innate immune after ischemic stroke. Scientific Reports, 3: 3177, 2013.
  26. Murase H., Shimazawa M., Kakino M., Ichihara K., Tsuruma K. and Hara H. The effects of Brazilian green propolis against excessive light-induced cell damage in retina and fibroblast cells. Evidence-Based Complementary and Alternative Medicine, 2013, Article ID 238279, 2013.

    2014年(20報)

  27. Morishita S., Oku H., Horie T., Tonari M., Kida T., Sugiyama T., Takai S., Hara H. and Ikeda T. Systemic simvastatin rescues retinal ganglion cells from optic nerve injury possibly through suppression of glial NF-κB activation. PLoS ONE, 9(1), e84387, 2014.
  28. Ono Y., Tanaka H., Takata M., Nagahara Y., Noda Y., Tsuruma K., Shimazawa M., Hozumi I., Hara H. SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models. Neuroscience Letters, 559, 174-178, 2014.
  29. Tsuruma K., Yamauchi M., Sugitani S., Otsuka T., Ohno Y., Nagahara Y., Ikegame Y., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Progranulin, a major secretedprotein of mouse adipose-derived stem cells, inhibits light-induced retinal degeneration. STEM CELLS Translational Medicine, 3:42-53, 2014.
  30. Inoue Y., Shimazawa M., Nakamura S., Imamura T., Sugitani S., Tsuruma K. and Hara H. Protective effects of placental growth factor on retinal neuronal cell damage. Journal of Neuroscience Research, 92, 329-337, 2014.
  31. Yoshino Y., Ishisaka M., Umigai N., Shimazawa M., Tsuruma K. and Hara H. Crocetin prevents amyloid β1-42-induced cell death in murine hippocampal cells. Pharmacology & Pharmacy, 5, 37-42, 2014.
  32. Ojino K., Shimazawa M., Ohno Y., Otsuka T., Tsuruma K. and Hara H. Protective effect of SUN N8075, a free radical scavenger, against excessive light-induced retinal damage in mice. Biological and Pharmaceutical Bulletin, 37, 424-430, 2014.
  33. Masuda T., Miyakubo H., Iinuma M. and Hara H. The antimicrobial effect of the extract of Canavalia gladiata on periodontal pathogen. Food Function, 13, 2-6, 2014.
  34. Umetsu R., Nishibata Y., Abe J., Suzuki Y., Hara H., Nagasawa H., Kinosada Y. and Nakamura M. Evaluation of the association between the use of oral anti-hyperglycemic agents and hypoglycemia in Japan by data mining of the Japanese adverse drug event report (JADER) database. Yakugaku Zasshi, 134, 299-304, 2014.
  35. Ogawa K., Kuse Y., Tsuruma K., Kobayashi S., Shimazawa M. and Hara H. Protective effects of bilberry and lingonberry extracts against blue light-emitting diode light-induced retinal photoreceptor cell damage in vitro. BMC Complementary and Alternative Medicine, 14:120, 2014.
  36. Takagi T., Kitashoji A., Iwawaki T., Tsuruma K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. Temporal activation of Nrf2 in the penumbra and Nrf2 activator-mediated neuroprotection in ischemia-reperfusion injury. Free Radical Biology & Medicine, 72, 124-133, 2014.
  37. Masuda T., Shimazawa M., Ishizuka F., Nakamura S., Tsuruma K. and Hara H. Tissue kallikrein (kallidinogenase) protects against retinal ischemic damage in mice. European Journal of Pharmacology, 738, 74-82, 2014.
  38. Kuse Y., Ogawa K., Tsuruma K., Shimazawa M., Hara H. Damage of photoreceptor-derived cells in culture induced by light emitting diode-derived blue light. Scientific Reports, 4: 5223, 2014.
  39. Omi T., Tanimukai H., Kanayama D., Sakagami Y., Tagami S., Okochi M., Morihara T., Sato M., Yanagida K.,  Kitashoji A., Hara H., Imaizumi K., Maurice T., Chevallier N., Marchal S., Takeda M. and Kudo T.  Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor. Cell Death & Disease, 5, e1332, 2014.
  40. Akizawa T., Tsuruta Y., Okada Y., Miyauchi Y., Suda A., Kasahara H., Sasaki N., Maeda Y., Suzuki T., Matsui N., Niwayama J., Suzuki T., Hara H., Asano Y., Komemushi S. and Fukagawa M. Effect of chitosan chewing gum on reducing serum phosphorus in hemodialysis patients: a multi-center, randomized, double-blind, placebo-controlled trial. BMC Nephrology, 15:98, 2014.
  41. Nakano Y., Suzuki Y., Takagi T., Kitashoji A., Ono Y., Tsuruma K., Yoshimura S., Shimazawa M., Iwama T. and Hara H. Glycoprotein nonmetastatic melanoma protein B (GPNMB) as a novel neuroprotective factor in cerebral ischemia reperfusion injury. Neuroscience, 277, 123-131, 2014.
  42. Mishiro K., Takahiko Imai T., Sugitani S., Kitashoji A., Suzuki Y., Takagi T., Chen H., Oumi Y., Tsuruma K., Shimazawa M. and Hara H. Diabetes mellitus aggravates hemorrhagic transformation after ischemic stroke via mitochondrial defects leading to endothelial apoptosis. PLoS ONE, 9(8), e103818, 2014.
  43. Lin W., Lu Y., Xu Y., He W., Kawase K., Yamamoto T., Shimazawa M. and Hara H. Effect of anti-glaucoma ophthalmic solutions on cultured human conjunctival cells. Chin. J. Pract Ophthalmol, 32, 512-516, 2014.
  44. Takagi T., Mishiro K., Shimazawa M., Yoshimura S., Iwama T. and Hara H. The phosphodiesterase III inhibitor cilostazol ameliorates ethanol-induced endothelial dysfunction. Current Neurovascular Research, 11, 302-311, 2014.
  45. Nakamura S., Shimazawa M., Inoue Y., Takata S., Ito Y., Tsuruma K.,  Ikeda T., Honda A., Satoh M. and Hara H. Role of metallothioneins 1 and 2 in ocular neovascularization. Invest. Ophthalmol. Vis. Sci., 55, 6851-6860, 2014.
  46. Imamura T., Hirayama T., Tsuruma K., Shimazawa M., Nagasawa H. and Hara H. Hydroxyl radicals cause fluctuation in intracellular ferrous ion levels upon light exposure during photoreceptor cell death. Experimental Eye Research, 129, 24-30, 2014.

2015年(22報)

  1. Kaneko M., Noguchi T., Ikegami S., Sakurai T., Kakita A., Toyoshima Y., Kambe T., Yamada M., Inden M., Hara H., Oyanagi K., Inuzuka T., Takahashi H. and Hozumi I.
    Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis.
    J. Neurosci. Res., 93, 2, 370-379, 2015.
  2. Tsujii S., Ishisaka M., Shimazawa M., Hashizume T. and Hara H.
    Zonisamide suppresses endoplasmic reticulum stress-induced neuronal cell damage in vitro and in vivo. European Journal of Pharmacology, 741, 301-307, 2015.
  3. Ishisaka M., Tsujii S., Mizoguchi T.,  Tsuruma K., Shimazawa M. and Hara H.
    The effects of valproate and olanzapine on the abnormal behavior of diacylglycerol kinase β knockout mice.
    Pharmacological Reports, 67, 2, 275-280, 2015.
  4. Hozumi Y., Kakefuda K., Yamasaki M., Watanabe M., Hara H. and Goto K.
    Involvement of diacylglycerol kinase β in the spine formation at distal dendrites of striatal medium spiny neurons. Brain Research, 1594, 36-45, 2015.
  5. Murata K., Yoshino Y., Tsuruma K., Moriguchi S., Oyagi A., Tanaka H., Ishisaka M., Shimazawa M., Fukunaga K., Hara H.
    The extracellular fragment of GPNMB improves memory and increases hippocampal GluA1 levels in mice. Journal of Neurochemistry, 132, 583-594, 2015.
  6. Abe J., Mataki K., Umetsu R., Ueda N., Kaato Y., Nakayama Y., Kinosada Y., Hara H., Inagaki N. and Nakamura M.
    Stevens-Johnson syndrome and toxic epidermal necrolysis: The Food and Drug Administration adverse event reporting system, 2004–2013.
    Allergol Int., 64(3), 277-279. 2015.
  7. Shimazawa M., Sugitani S., Inoue Y., Tsuruma K. and Hara H.
    Effect of a sigma-1 receptor agonist, cutamesine dihydrochloride (SA4503), on photoreceptor cell death against light-induced damage.
    Experimental Eye Research, 132, 64-72, 2015.
  8. Yoshino Y., Ishisaka M., Tsujii S., Shimazawa M. and Hara H.
    Glucagon-like peptide-1 protects the murine hippocampus against stressors via Akt and ERK1/2 signaling. Biochemical and Biophysical Research Communications, 458, 274-279, 2015.
  9. 柿野衛、田澤茂実、丸山広恵、荒木陽子、市原賢二、河野宏行、飯沼宗和、原英彰
    ジンチョウゲ科ジンコウ属(Aquilaria属)植物の葉部エキス含有食品の二重盲検クロスオーバーによる有効性試験ならびに安全性試験 A double-blinded, placebo-controlled, crossover trial and open-label safety trials of extract of Aquilaria sp (Thymelaeaceae) leaves.
    Jpn. Pharmacol. Ther.(薬理と治療), 43, 209-229, 2015.
  10. Shimazawa M., Masuda T., Nakamura N., Miwa M., Nakamura K. and Hara H.
    An experimental model for exudative age-related macular degeneration with choroidal neovascularization using the common marmoset.
    Current Neurovascular Research, 12, 128-134, 2015.
  11. Suzuki Y., Suzuki H., Umetsu R., Uranishi H., Abe J., Nishibata Y., Sekiya Y., Miyamura N., Hara H., Tsuchiya T., Kinosada Y. and Nakamura M.
    The analysis of the interaction between clopidogrel, aspirin and proton pump inhibitors using the FDA Adverse Event Reporting System database.
    Biological and Pharmaceutical Bulletin, 38, 680–686, 2015.
  12. Noda Y., Shimazawa M., Tanaka H., Tamura S., Inoue T., Tsuruma K. and Hara H.
    VGF and striatal cell damage in in vitro and in vivo models of Huntington’s disease.
    Pharmacology Research & Perspectives, 3, e00140, 2015.
  13. Murase H., Tsuruma K., Shimazawa M. and Hara H.
    TUDCA promotes phagocytosis by retinal pigment epithelium via MerTK activation.
    Invest. Ophthalmol. Vis. Sci., 56, 2511–2518, 2015.
  14. Takata S.#, Masuda T.# , Nakamura S.,  Kuchimaru T., Tsuruma K., Shimazawa M., Nagasawa H., Kondoh S. and Hara H. #
    Contributted equally, The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe.
    Scientific Reports, 5: 9898, 2015.
  15. Kanematsu M., Futamura M., Takata M., Gaowa S., Yamada A., Morimitsu K., Morikawa A., Mori R., Hara H. and Yoshida K.
    Clinical significance of glycoprotein non-metastatic B and its association with HER2 in breast cancer. Cancer Medicine,  4,1344-1355, 2015.
  16. Ohba T., Yoshino Y., Ishisaka M., Abe N., Tsuruma K., Shimazawa M., Oyama M., Tabira T. and Hara H. Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice.
    Bioscience, Biotechnology, and Biochemistry, 79, 1838-1844, 2015.
  17. Tsuruma K., Takano N., Imai S., Saito Y., Ito T. and Hara H.
    Investigation of preventive effects of propolis and its constituents against age-related macular degeneration.
    Food Function, 14, 25-31, 2015.
  18. Nagahara Y., Shimazawa M., Tanaka H., Ono Y., Noda Y., Ohuchi K., Tsuruma K., Katsuno M., Sobue G. and Hara H.
    GPNMB ameliorates skeletal muscle lesions in a SOD1G93A mouse model of amyotrophic lateral sclerosis.
    J. Neurosci. Res., 93, 1552–1566, 2015.
  19. Fuma S., Murase H., Kuse Y., Tsuruma K., Shimazawa M. and Hara H.
    Photobiomodulation of 670 nm light increased the phagocytosis in the human retinal pigment epithelial cells.
    Molecular Vision, 21, 883-892, 2015.
  20. Ojino K., Shimazawa M., Izawa H., Nakano Y., Tsuruma K. and Hara H.
    The involvement of endoplasmic reticulum stress in optic nerve degeneration after chronic high intraocular pressure in DBA/2J mice.
    J. Neurosci. Res., 93, 1675-1683, 2015.
  21. Izawa H., Inoue Y., Ohno Y., Ojino K., Tsuruma K., Shimazawa M. and Hara H.
    Protective effects of anti-placental growth factor antibody against light-induced retinal damage in mice. Invest. Ophthalmol. Vis. Sci., 56, 6914-6924, 2015.
  22. Saito Y., Tsuruma K., Ichihara K., Shimazawa M. and Hara H.
    Brazilian green propolis water extract up-regulates the early expression level of HO-1 and accelerates Nrf2 after UVA irradiation.
    BMC Complementary and Alternative Medicine, 15:421, 2015.

2016年 (19報)

  1. Ooe E., Ogawa K., Horiuchi T., Tada H., Murase H., Tsuruma K., Shimazawa M. and Hara H.
    Analysis and characterization of anthocyanins and carotenoids in japanese blue tomato.
    Bioscience, Biotechnology, and Biochemistry, 80(2), 341-349, 2016.
  2. Ohuchi K., Funato M., Kato Z., Seki J., Kawase C., Tamai Y., Ono Y., Nagahara Y., Noda Y., Kameyama T., Ando S., Tsuruma K., Shimazawa M., Hara H. and Kaneko H.
    Established stem cell model of spinal muscular atrophy is applicable in the evaluation of the efficacy of thyrotropin-releasing hormone analog.
    STEM CELLS Translational Medicine, 5, 152-163, 2016.
  3. Fuma S., Shimazawa M., Imamura T., Kanno Y., Takano N., Tsuruma K. and Hara H.
    Neuroprotective effect of ocular hypotensive drugs: Latanoprost/timolol in combination are more effective than each as monotherapy in RGC-5.
    Biol. Pharm. Bull., 39(2), 192-198, 2016. Highlighted Paper selected by Editor-in-Chief (The selection is based upon originally, scientific contributions, methodological pertinence, and composition.)
  4. Otsuka T., Shimazawa M., Inoue Y., Nakano Y., Ojino K., Izawa H., Tsuruma K., Ishibashi T. and Hara H.
    Astaxanthin protects against retinal damage: Evidence from in vivo and in vitro retinal ischemia and reperfusion models.
    Current Eye Research, Volume 41, Issue 11. 1465-1472, 2016.
  5. Mizoguchi T., Ishisaka M., Kobatake Y., Kamishina H., Nishioka Y., Kirimoto T., Shimazawa M. and Hara H.
    Establishment and effects of ginger and kikyoto of a haloperidol-induced dysphagia model in guinea pigs.
    Pharmacology & Pharmacy, 7(2), 97-105, 2016.
  6. Imai T., Takagi T., Kitashoji A., Yamauchi K., Shimazawa M. and Hara H.
    Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation.
    Neurobiology of Disease, 89, 136-146, 2016.
  7. Ono Y.,  Tsuruma K., Takata M., Shimazawa M. and Hara H.
    Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na+/K+-ATPase.
    Scientific Reports, 6, 23241, 2016.
  8. Hiromoto K., Kuse Y., Tsuruma K., Tadokoro N., Kaneko N., Shimazawa M. and Hara H.
    Colored lenses suppress blue light-emitting diode light-induced damage in photoreceptor-derived cells.
    J. Biomed. Opt., 21(3), 035004, 2016.
  9. Kuse Y.,  Tsuruma K., Sugitani S., Izawa H., Ohno Y., Shimazawa M. and Hara H.
    Progranulin promotes the retinal precursor cell proliferation and the photoreceptor differentiation in the mouse retina.
    Scientific Reports, 6, 23811, 2016.
  10. Masuda T., Shimazawa M., Takata S., Nakamura S., Tsuruma K. and Hara H.
    Edaravone is a free radical scavenger that protects against laser-induced choroidal neovascularization in mice and common marmosets.
    Exp. Eye Res., 146, 196-205, 2016
  11. Izawa H., Shimazawa M., Inoue Y., Uchida S., Moroe H., Tsuruma K. and Hara H.
    Protective effects of NSP-116, a novel imidazolyl aniline derivative, against light-induced retinal damage in vitro and in vivo
    Free Radic. Biol. Med., 96, 304-312, 2016.
  12. Ohuchi K., Tsuruma K., Shimazawa M., Nakamura J. and Hara H.
    The novel cPLA2 inhibitor AK106-001616 has a protective effect on SOD1G93A -induced cell death in NSC34 murine motor neuron-like cells.

    Pharmacology & Pharmacy, 7(5), 193-199, 2016.
  13. Kawase R., Nishimura Y., Ashikawa Y., Sasagawa S., Murakami S., Yuge M., Okabe S., Kawaguchi K., Yamamoto H., Moriyuki K., Yamane S., Tsuruma K., Shimazawa M., Hara H. and Tanaka T.
    EP300 Protects from Light-induced Retinopathy in Zebrafish
    Frontiers in Pharmacology, 7:126, 2016.
  14. Saito Y., Tsuruma K., Shimazawa M., Nishimura Y., Tanaka T. and Hara H.
    Establishment of a drug evaluation model against light-induced retinal degeneration using adult pigmented zebrafish
    J Pharmacol. Sci., 131(3), 215-218, 2016.
  15. Ohba T., Ishisaka M., Tsujii S., Tsuruma K., Shimazawa M., Kubo K., Umigai N., Iwawaki T. and Hara H.
    Crocetin protects ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo
    European Journal of Pharmacology, 789, 244-253, 2016.
  16. Yamauchi K., Nakanoa Y., Takagi T., Tsuruma K., Shimazawa M., Iwama T. and Hara H.
    A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice
    Neuroscience, 333, 302-310, 2016.
  17. Kakefuda K., Ishisaka M., Tsuruma K., Shimazawa M. and Hara H.
    Memantine, an NMDA receptor antagonist, improves working memory deficits in DGK (beta) knockout mice
    Neuroscience Letters,630, 228-232, 2016.
  18. Ono Y., Chiba S., Yano H., Nakayama N., Saio M., Tsuruma K., Shimazawa M., Iwama T. and Hara H.
    Glycoprotein nonmetastatic melanoma protein B (GPNMB) promotes the progression of brain glioblastoma via Na+/K+-ATPase.
    Biochemical and Biophysical Research Communications, 481, 7-12, 2016.
  19. Sawada S., Ono Y., Egashira Y., Takagi T., Tsuruma K., Shimazawa M., Iwama T. and Hara H.
    In models of intracerebral hemorrhage, rivaroxaban is superior to warfarin to limit blood brain barrier disruption and hematoma expansion.
    Current Neurovascular Research, Volume 13 (E-pub ahead of print), 2016.

    2017年(37報)

  20. 1 Takagi T., Mishiro K., Tsujimoto M., Ito H., Imai T., Nagashima K., Tsuruma K., Shimazawa M., Yoshimura S., Kozawa O., Iwama T. and Hara H.
    Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood–brain barrier.
    Journal of Cerebral Blood Flow and Metabolism, 37(1), 123-139 2017.
  21. 2 Shimazawa M., Inoue Y., Masuda T., Onodera R., Tahara K., Shimizu Y., Mibe Y., Tsuruma K., Takeuchi H. and Hara H.
    Topical diclofenac-loaded liposomes ameliorate laser-induced choroidal neovascularization in mice and non-human primates
    Current Neurovascular Research, 14(1): 46-52, 2017.
  22. 3 Imai T., Mishiro K., Takagi T., Isono A., Nagasawa H., Tsuruma K., Shimazawa M. and Hara H.
    Protective effect of bendavia (SS-31) against oxygen/glucose-deprivation stress-induced mitochondrial damage in human brain microvascular endothelial cells
    Current Neurovascular Research, 14(1): 53-59, 2017.
  23. 4 Nagahara Y., Shimazawa M., Ohuchi K., Ito J., Takahashi H., Tsuruma K., Kakita A. and Hara H.
    GPNMB Ameliorates Mutant TDP-43-Induced Motor Neuron Cell Death.
    Journal of Neuroscience Research, 95(8): 1647-1665, 2017.
  24. 5 Wan-Ju Chen, Caiying Wu, Zhenhua Xu, Kuse Y., Hara H. and Elia Duh.
    Nrf2 protects photoreceptor cells from photo-oxidative stress induced by blue light.
    Exp. Eye Res., 154, 151-158, 2017.
  25. 6 Shimoda M., Yoshida H., Mizuno S., Hirozane H., Horiuchi K., Yoshino Y., Hara H., Kanai Y., Inoue S., Ishijima M. and Okada Y.
    HYBID (hyaluronan binding protein involved in hyaluronan depolymerization, KIAA1199) controls endochondral ossification through hyaluronan metabolism
    The American Journal of Pathology, 187(5): 1162–1176, 2017.
  26. 7 Masuda T., Shimazawa M., Hashimoto Y., Kojima A., Nakamura S., Suemori S., Mochizuki K., Kawakami H., Kawase K., and Hara H.
    Apolipoprotein E2 and E3, but not E4, promote retinal pathological neovascularization
    Investigative Ophthalmology & Visual Science, 58, 1208-1217, 2017.
  27. 8  Fuma S., Nishinaka A., Inoue Y., Tsuruma K., Shimazawa M., Kondo M. and Hara H.
    A pharmacological approach in newly established retinal vein occlusion model
    Scientific Reports, 7, 43509, 2017.
  28. 9  Yoshino Y., Ishisaka M., Tsuruma K., Shimazawa M., Yoshida H., Inoue S., Shimoda M., Okada Y. and Hara H.
    Distribution and function of hyaluronan binding protein involved in hyaluronan depolymerization (HYBID, KIAA1199) in the mouse central nervous system
    Neuroscience, 347, 1-10, 2017.
  29. 10  Ooe E., Tsuruma K., Kuse Y., Kobayashi S., Shimazawa M. and Hara H.
    The involvement of ATF4 and S-opsin in retinal photoreceptor cell damage induced by blue LED light.
    Molecular Vision, 23, 52-59, 2017.
  30. 11  Nakano Y., Shimazawa M., Ojino K., Izawa H., Takeuchi H., Inoue Y., Tsuruma K. and Hara H.
    Toll-like receptor 4 inhibitor protects against retinal ganglion cell damage induced by optic nerve crush in mice
    Journal of Pharmacological Sciences, 133(3): 176-183, 2017.
  31. 12  Imai T.#, Matsukawa H.#, Takagi T., Tsuruma K., Shimazawa M. and Hara H.
    #Contributed equally
    The phosphodiesterase III inhibitor cilostazol protects the brain microvasculature from collagenase injury
    NeuroReport, 28(10), 555-560, 2017.
  32. 13  Imamura T., Tsuruma K., Inoue Y., Otsuka T., Ohno Y., Ogami S., Yamane S., Shimazawa M. and Hara H.
    Rimonabant, a selective cannabinoid1 receptor antagonist, protects against light-induced retinal degeneration in vitro and in vivo
    European Journal of Pharmacology, 803, 78-83, 2017.
  33. 14  Inoue Y., Shimazawa M., Noda Y., Nagano R., Otsuka T., Kuse Y., Nakano Y., Tsuruma K., Nakagami Y. and Hara H.
    RS9, a novel Nrf2 activator, attenuates light-induced death of cells of photoreceptor cells and Müller glia cells.
    Journal of Neurochemistry, 141, 5, 750-765, 2017.
  34. 15  Noguchi T., Shimazawa M., Hamaguchi K., Araki T., Horai N. and Hara H.
    Relationship between elevated intraocular pressure and divided peripapillary sector retinal nerve fiber layer thickness in a cynomolgus monkey laser-induced ocular hypertension model
    Ophthalmic Research, 58, 2, 99-106, 2017.
  35. 16  Kuse Y., Tsuruma K., Kanno Y., Shimazawa M. and Hara H.
    CCR3 is associated with death of cells of photoreceptor cell-line induced by light exposure.
    Frontiers in Pharmacology, 8(5223), 2017.
  36. 17  Kuse Y., Tsuruma K., Mizoguchi T., Shimazawa M. and Hara H.
    Progranulin deficiency causes the retinal ganglion cell loss during development.
    Scientific Reports, 7, 1679, 2017.
  37. 18  Nishida T., Kuse Y., Mochizuki K., Shimazawa M., Yamamoto T. and Hara H.
    Protective effects of fluoroquinolones on UV-induced damage of cultured ocular cell lines
    European Journal of Pharmacology, 806, 59-66, 2017.
  38. 19  Nakamura M., Kuse Y., Tsuruma K., Shimazawa M. and Hara H.
    The involvement of the oxidative stress in murine blue LED light-induced retinal damage model
    Biol. Pharm. Bull., 40, 8, 1219-1225, 2017.
  39. 20  Murase H., Tsuruma K., Kuse Y., Shimazawa M. and Hara H.
    Progranulin Increases Phagocytosis by Retinal Pigment Epithelial Cells in Culture
    Journal of Neuroscience Research, 95(12), 2500-2510, 2017.
  40. 21  Mizoguchi T., Minakuchi H., Ishisaka M., Tsuruma K., Shimazawa M. and Hara H.
    Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF.
    Scientific Reports, 7, 4691, 2017.
  41. 22  Kustiawan P.M.#, Okuyoshi H.#,  Kuse Y., Izawa H., Saito Y., Tsuruma K., Chanchao C., Hara H. and Shimazawa M.
    #Contributed equally
    Protective Effects of Indonesian Propolis Against Light-Induced Retinal Damage.
    International Journal of Toxicological and Pharmacological Research, 92, 163-170, 2017.
  42. 23  Inoue Y., Shimazawa M, Nagano R., Kuse Y., Takahashi K., Tsuruma K., Hayashi M., Ishibashi T., Maoka T. and Hara H.
    Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration.
    Journal of Pharmacological Sciences, 134, 147-157, 2017.
  43. 24  Nishinaka A., Fuma S., Inoue Y., Shimazawa M. and Hara H.
    Effects of kallidinogenase on retinal edema and size of non-perfused areas in mice with retinal vein occlusion
    Journal of Pharmacological Sciences, 134, 2, 86-92, 2017.
  44. 25  Kuse Y., Nakamura M., Yako T., Kunihiro C., Shimazawa M. and Hara H.
    Comparison of Retinal Damage Induced by Electrodeless Lamp and White LED in Mice.
    Atarashii Ganka (Journal of the Eye) 34(5), 749-753, 2017.
  45. 26  Imai S., Otsuka T., Naito A., Shimazawa M. and Hara H.
    Triamcinolone Acetonide Suppresses Inflammation and Facilitates Vascular Barrier Function in Human Retinal Microvascular Endothelial Cells.
    Current Neurovascular Research, 14(3), 232-241, 2017.
  46. 27  Tanaka M.#, Yoshino Y.#, Takeda S., Toda K., Shimoda H., Tsuruma K., Shimazawa M. and Hara H.
    Fermented rice germ extract alleviates morphological and functional damage to murine gastrocnemius muscle via inactivation of AMP-activated protein kinase
    Journal of Medicinal Food, 20(10), 969-980, 2017.
  47. 28  Sakata C., Kawasaki T., Iwatsuki Y., Moritani Y., Morita Y. and Hara H.
    Inhibitory effects of ASP6537, a selective cyclooxygenase-1 inhibitor, on thrombosis and neointima formation in rats
    Thrombosis Research, 157, 72-78, 2017.
  48. 29  Momose K., Takenaka T., Nakamura M. and Hara H.
    Drug discovery support processes from Japanese academia -An innovative drug development support measure from 1990 through 2017-
    The Japanese Journal of History of Pharmacy, 52, 1, 51-63, 2017.
  49. 30  Tokunaga E., Akiyama H., Soloshonok V., Inoue Y., Hara H. and Shibata N.
    Biological evaluation of both enantiomers of fluoro-thalidomide using human myeloma cell line H929 and others
    PLOS ONE, 12(8):e0182152, 2017.
  50. 31  Kuroda A., Enomoto N., Ishida K., Shimazawa M., Noguchi T., Horai N., Onoe H., Hara H. and Tomita G.
    Movement of retinal vessels toward the optic nerve head after increasing intraocular pressure in monkey eyes with experimental glaucoma.
    Experimental Eye Research, 162, 110-115, 2017.
  51. 32  Horibe M.#, Yoshino Y.#, Domoto S., Nakamura M., Shimazawa M. and Hara H.
    The effects of blue LED light on behavior and retinal function in maternal and offspring mice.
    Journal of Behavioral and Brain Science, 7, 348-359, 2017.
  52. 33  Ando S., Funato M., Ohuchi K., Kameyama T., Inagaki S., Seki J., Kawase C., Tsuruma K.,  Shimazawa M., Kaneko H. and Hara H.
    Edaravone is a candidate agent for spinal muscular atrophy: in vitro analysis using a human induced pluripotent stem cells-derived disease model.
    European Journal of Pharmacology, 814, 161-168, 2017.
  53. 34 Noda Y.#, Tsuruma K.#, Takata M.#, Ishisaka M., Tanaka H., Nakano Y., Nagahara Y., Shimazawa M. and Hara H.
    #Contributed equally
    GPNMB Induces BiP Expression by Enhancing Splicing of BiP Pre-mRNA during the Endoplasmic Reticulum Stress Response.
    Scientific Reports, 7, 12160, 2017.
  54. 35 Yamauchi K., Imai T., Shimazawa M., Iwama T. and Hara H.
    Effects of ticagrelor in a mouse model of ischemic stroke.
    Scientific Reports, 7, 12088, 2017.
  55. 36 Ohno Y., Otsuka Y., Nohara M., Furihata T., Kuse Y., Itoh Y., Hara H. and Anzai N.
    Characterization of an L-carnitine transport system in murine photoreceptor cell line.
    Biol. Pharm. Bull., 40, 2110-2116, 2017.
  56. 37 Takahashi K., Shimazawa M., Izawa H., Inoue Y., Kuse Y. and Hara H.
    Platelet-derived growth factor-BB lessens light-induced rod photoreceptor damage in mice
    Investigative Ophthalmology & Visual Science, 58, 14, 6299-6307, 2017.

    2018年

  57. 1 Imamura T., Tsuruma K., Inoue Y., Otsuka T., Ohno Y., Ogami S., Yamane S., Shimazawa M. and Hara H.
    Involvement of cannabinoid receptor type 2 in light-induced degeneration of cells from mouse retinal cell line in vitro and mouse photoreceptors in vivo
    Experimental Eye Research, 167, 44-50, 2018.
  58. 2  Domoto S., Ohba T., Yoshino Y., Horibe M., Yako T., Shimazawa M. and Hara H.
    Exposure to blue LED light at subjective daytime does not affect brain function in pigmented mice.
    Journal of Science and Technology in Lighting, 41, 22-29, 2017.
  59. 3 Inoue Y., Shimazawa M., Nakamura S., Takata S., Hashimoto Y., Izawa H., Masuda T., Tsuruma K., Sakaue T., Nakayama H., Higashiyama S. and Hara H.
    Both autocrine and paracrine signaling of heparin-binding epidermal growth factor-like growth factor enhances ocular neovascularization
    Arteriosclerosis, Thrombosis, and Vascular Biology, 38, 174-185, 2018.
  60. 4  Mizoguchi T.#, Minakuchi H.#, Tanaka M., Tsuruma K., Shimazawa M. and Hara H.
    #Contributed equally
    Sensorimotor gating deficits and effects of antipsychotics on the hyperactivity in VGF-overexpressing mice.
    Pharmacological Reports, 70, 476-480, 2018.
  61. 5  Horibe M, Hane Y, Abe J, Matsui T, Kato Y, Ueda N, Sasaoka S, Motooka Y, Hatahira H, Hasegawa S, Kinosada Y, Hara H, Nakamura M.
    Contraceptives as possible risk factors for postpartum depression: a retrospective study of the Food and Drug Administration Adverse Event Reporting System, 2004–2015
    Nursing Open, 5, 131-138, 2018.
  62. 6  Inagaki S, Kawase K, Funato M, Seki J, Kawase C, Ohuchi K, Kameyama T, Ando S, Morozumi W, Nakamura S, Shimazawa M, Iejima D, Iwata T, Yamamoto T, Kaneko H and Hara H
    Effect of timolol on optineurin aggregation in transformed induced pluripotent stem cells derived from patient with familial glaucoma.
    Investigative Ophthalmology & Visual Science, 59, 2293-2304, 2018.
  63. 7  Arimura S, Takamura Y, Miyake S, Kojima A, Sakurai S, Turuma K, Hara H and Inatani M
    Inhibitory Effect of Alpha-Crystallins on VEGF-Induced Proliferation of Retinal Microvascular Endothelial Cells
    J Clin Exp Ophthalmol 2018, 9:1
  64. 8 Hida Y, Nakamura S, Nishinaka A, Inoue Y, Shimazawa M and Hara H
    Effects of ripasudil, a ROCK inhibitor, on retinal edema and nonperfusion area in a retinal vein occlusion murine model.
    Journal of Pharmacological Sciences, 137(2), 129-136, 2018.
  65. 9 Horibe M, Sasaoka S, Naganuma M, Hasegawa S, Hara H and Nakamura M
    Analysis of mother’s sentiments regarding postpartum depression by text mining: Based on contents of remarks on social media.
    Japanese Journal of Nursing and Health Sciences, 16, 53-63, 2018.
  66. 10 Ohuchi K, Ono Y, Joho M, Tsuruma K, Ogami S, Yamane S, Funato M, Kaneko H, Nakamura S, Hara H and Shimazawa M
    A docosahexaenoic acid-derived pro-resolving agent, maresin 1, protects motor neuron cells death.
    Neurochemical Research, 43(7), 1413-1423, 2018.
  67. 11 Moriguchi M, Nakamura S, Inoue Y, Nishinaka A, Nakamura M, Shimazawa M and Hara H
    Irreversible photoreceptors and RPE cells damage by intravenous sodium iodate in mice is related to macrophage accumulation
    Investigative Ophthalmology & Visual Science, 59, 3476-3487, 2018.
  68. 12 Kuse Y, Ohuchi K, Nakamura S, Hara H and Shimazawa M
    Microglia increases the proliferation of retinal precursor cells during postnatal development
    Molecular Vision, 24, 536-545, 2018.
  69. 13 Nakamura M, Yako T, Kuse Y, Inoue Y, Nishinaka A, Nakamura S, Shimazawa M and Hara H
    Exposure to excessive blue LED light damages retinal pigment epithelium and photoreceptors of pigmented mice
    Experimental Eye Research, 177, 1-11, 2018.
  70. 14 Kuse Y, Takahashi K, Inoue Y, Izawa H, Nakamura S, Shimazawa M and Hara H
    Intravitreal aflibercept protects photoreceptors of mice against excessive light exposure
    Journal of Pharmacological Sciences, 137, 407-411, 2018.
  71. 15 Yoshino Y, Shimazawa M, Nakamura S, Inoue S, Yoshida H, Shimoda M, Okada Y and Hara H
    Targeted deletion of HYBID (hyaluronan binding protein involved in hyaluronan depolymerization/ KIAA1199/CEMIP) decreases dendritic spine density in the dentate gyrus through hyaluronan accumulation
    Biochemical and Biophysical Research Communications,503(3),1934-1940,2018.
  72. 16 Ooe E, Kuse Y, Yako T, Sogon T, Nakamura S, Hara H and Shimazawa M
    Bilberry extract and anthocyanins suppress unfolded protein response induced by blue LED light exposure of cells in photoreceptor cell line
    Molecular Vision,24, 621-32, 2018.
  73. 17 Iwata S, Imai T, Shimazawa M, Ishibashi T, Hayashi M, Hara H and Nakamura S
    Protective effects of the astaxanthin derivative, adonixanthin, on brain hemorrhagic injury
    Brain Research, 1698, 130-138, 2018.
  74. 18 Nishinaka A, Inoue Y, Fuma S, Hida Y, Nakamura S, Shimazawa M and Hara H
    Pathophysiological role of VEGF on retinal edema and nonperfused areas in mouse eyes with retinal vein occlusion
    Investigative Ophthalmology & Visual Science, 59, 4701-4713, 2018.
  75. 19 Saito Y, Gouda T, Nakamura S, Ichihara K, Hara H and Shimazawa M
    Water extract of Brazilian green propolis attenuates high glucose-induced vascular morphological abnormality in zebrafish
    Journal of Functional Foods,in press.
  76. 20 Sugiyama T, Imai T, Nakamura S, Yamauchi K, Sawada S, Shimazawa M and Hara H
    A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase
    Brain Research, 1701, 137-145, 2018.
  77. 21 Saito Y, Kuse Y, Inoue Y, Nakamura S, Hara H and Shimazawa M
    Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival
    Redox Biology,19, 354-363, 2018.
  78. 22 Yoshino Y, Goto M, Hara H and Inoue S
    The role and regulation of TMEM2 (transmembrane protein 2) in HYBID (hyaluronan (HA)-binding protein involved in HA depolymerization/ KIAA1199/CEMIP)-mediated HA depolymerization in human skin fibroblasts
    Biochemical and Biophysical Research Communications,in press.
  79. 23 Yokota S, Kobatake Y, Noda Y, Nakata K, Yamato O, Hara H, Sakai H, Nishida H, Maeda S, Kamisina H
    Activation of the unfolded protein response in canine degenerative myelopathy
    Neuroscience Letters, 687, 216-222, 2018.
  80. 24 Takeuchi H,Inagaki S, Morozumi W, Nakano Y, Inoue Y, Kuse Y, Mizoguchi T, Nakamura S, Funato M, Kaneko H, Hara H and Shimazawa M
    VGF nerve growth factor inducible is involved in retinal ganglion cells death induced by optic nerve crush
    Scientific Reports, 8, 16443, 2018
  81. 25 Tsuruma K, Saito Y, Okuyoshi H, Yamaguchi A, Shimazawa M, Goldman D and Hara H
    Granulin 1 Promotes Retinal Regeneration in Zebrafish
    Investigative Ophthalmology & Visual Science, in press.
  82. 26 Yako T, Kuse Y, Nakamura S, Shimazawa M, Motomura T and Hara H
    The Protective Effect of Blue Light Cutting Particles Mixed Optical Material against Blue LED light-Induced Photoreceptor and Cornea Cell Death
    Journal of Science and Technology in Lighting, in press.
  83. 27 Mizoguchi T, Shimazawa M Ohuchi K, Kuse Y, Nakamura S and Hara H
    Impaired cerebellar development in mice overexpressing VGF
    Neurochemical Research, in press.
  84. 28 Kameyama T, Ohuchi K, Funato M, Ando S, Inagaki S, Sato A, Seki J, Kawase C, Tsuruma K, Nishino I, Nakamura S, Shimazawa M, Saito T, Takeda S, Kaneko H and Hara H
    Efficacy of Prednisolone in Generated Myotubes Derived from Fibroblasts of Duchenne Muscular Dystrophy Patients
    Frontiers in pharmacology, in press.
  85. 29 Matsuo M, Kuse Y, Takahashi K, Kuwahara K, Tanito M, Kaidzu S, Shimazawa M, Hara H and Ohira A
    Carteolol hydrochloride reduces visible light-induced retinal damage in vivo and BSO/glutamate-induced oxidative stress in vitro
    Jounal of Pharmacological Sciences, in press.
  86. 30 Ohuchi K, Funato M, Yoshino Y, Ando S, Inagaki S, Sato A, Kawase C, Seki J, Saito T, Nishio H, Nakamura S, Shimazawa M, Kaneko H and Hara H
    Notch Signaling Mediates Astrocyte Abnormality in Spinal Muscular Atrophy Model Systems
    Scientific Reports, in press.

Page Top