原著論文

 

Original papers


2018年

  • Eguchi, H., Akizuki, R., Maruhashi, R., Tsukimoto, M., Furuta, T., Matsunaga, T., Endo, S. and Ikari, A., Increase in resistance to anticancer drugs involves occludin in spheroid culture model of human lung adenocarcinoma A549 cells. Sci. Rep., 8, 15157 (2018)
  • Takashina, Y., Manabe, A., Hasegawa, H., Matsunaga, T., Endo, S. and Ikari, A., Sodium citrate increases expression and flux of Mg2+ transport carriers mediated by activation of MEK/ERK/c-Fos pathway in renal tubular epithelial cells. Nutrients, 10, E1345 (2018)
  • Sonoki H, Tanimae A, Furuta T, Endo S, Matsunaga T, Ichihara K and Ikari A., Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells. J. Nutr. Biochem., 56, 205-214 (2018)
  • Akizuki R, Maruhashi R, Eguchi H, Kitabatake K, Tsukimoto M, Furuta T, Matsunaga T, Endo S and Ikari A., Decrease in paracellular permeability and chemosensitivity to doxorubicin by claudin-1 in spheroid culture models of human lung adenocarcinoma A549 cells. Biochem. Biophys. Acta., 1865, 769-780 (2018)
  • Endo, S., Hoshi, M., Matsunaga, T., Inoue, T., Ichihara, K. and Ikari, A., Autophagy inhibition enhances anticancer efficacy of artepillin C, a cinnamic acid derivative in Brazilian green propolis. Biochem. Biophys. Res. Commun., 497, 437-443 (2018)
  • Maruhashi, R., Akizuki, R., Sato, T., Matsunaga, T., Endo, S., Yamaguchi, M., Yamazaki, Y., Sakai, H. and Ikari, A. Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models. Biochim. Biophys. Acta, 1865, 470-479 (2018)
  • Matsunaga, T., Kamase, K., Takasawa, H., Yamaji, Y., Endo, S., El-Kabbani, O., Ikari, A., Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1, Chem. Biol. Interact., 279, 10-20 (2018)

2017年

  • Endo, S., Xia, S., Suyama, M., Morikawa, Y., Oguri, H., Hu, D., Ao, Y., Takahara, S., Horino, Y., Hayakawa, Y., Watanabe, Y., Gouda, H., Hara, A., Kuwata, K., Toyooka, N., Matsunaga, T. and Ikari, A., Synthesis of potent and selective inhibitors of aldo-keto reductase 1B10 and their efficacy against proliferation, metastasis and cisplatin resistance of lung cancer cells, J. Med. Chem., 60, 8441-8455 (2017)
  • Furukawa, C., Ishizuka, N., Hayashi, H., Fujii, N., Manabe, A., Tabuchi, Y., Matsunaga, T., Endo, S. and Ikari, A., Up-regulation of claudin-2 expression by aldosterone in colonic epithelial cells of mice fed with NaCl-depleted diets. Sci. Rep., 7, 12223 (2017)
  • Matsunaga, T., Morikawa, Y., Kamase, K., Horinouchi, M., Sasajima, Y., Suenami, K., Sato, K., Takekoshi, Y., Endo, S., El-Kabbani, O. and Ikari, O., Enhancement of Endothelial Barrier Permeability by Mitragynine, Biol. Pharm. Bull., 40, 1779-1783 (2017)
  • Manabe, A., Furukawa, C., Endo, S., Marunaka, K., Nishiyama, T., Fujii, N., Tabuchi, Y., Matsunaga, T. and Ikari, A., Chlorpheniramine increases paracellular permeability to marker fluorescein lucifer yellow mediated by internalization of occludin in murine colonic epithelial cells, Biol. Pharm. Bull., 40, 1299-1305 (2017)
  • Marunaka, K., Furukawa, C., Fujii, N., Kimura, T., Furuta, T., Matsunaga, T., Endo, S., Hasegawa, H., Anzai, N., Yamazaki, Y., Yamaguchi, M. and Ikari A., The RING Finger- and PDZ Domain-Containing Protein PDZRN3 Controls Localization of the Mg2+ Regulator Claudin-16 in Renal Tube Epithelial Cells., J. Biol. Chem., 292, 13034-13044 (2017)
  • Sonoki, H., Tanimae, A., Endo, S., Matsunaga, T., Furuta, T., Ichihara, K. and Ikari, A., Kaempherol and chrysin decrease claudin-2 expression mediated by inhibition of STAT3 in lung adenocarcinoma A549 cells, Nutrients, 9, E597 (2017)
  • Matsunaga, T., Morikawa, Y., Kamata, K., Shibata, A., Miyazono, H., Sasajima, Y., Suenami, K., Sato, K., Takekoshi, Y., Endo, S., El-Kabbani, O. and Ikari, A., α-Pyrrolidinononanophenone provokes apoptosis of neuronal cells through alterations in antioxidant properties, Toxicology, 386, 93-102 (2017)
  • Matsunaga, T., Morikawa, Y., Tanigawa, M., Kamata, K., Shibata, A., Sasajima, Y., Suenami, K., Sato, K., Takekoshi ,Y., Endo, S., El-Kabbani, O. and Ikari, A., Structure-activity relationship for toxicity of α-pyrrolidinooctanophenone derivatives to endothelial cells, Forensic Toxicol., 35, 309-316 (2017)
  • Endo, S., Takada, S., Honda, R.P., Müller, K., Weishaupt, J.H., Andersend, P.M., Ludolph, A.C., Kamatari, Y.O., Matsunaga, T., Kuwata, K., El-Kabbani, O. and Ikari, A., Instability of C154Y variant of aldo-keto reductase 1C3, Chem. Biol. Interact., 276, 194-202 (2017)
  • Furukawa, C., Fujii, N., Manabe, A., Matsunaga, T., Endo, S., Hasegawa, H., Ito, Y., Yamaguchi, M., Yamazaki, Y. and Ikari, A., Up-regulation of transient receptor potential melastatin 6 channel expression by tumor necrosis factor-a in the presence of epidermal growth factor receptor tyrosine kinase inhibitor. J. Cell. Physiol., 232, 2841-2850 (2017)
  • Hichino, A., Okamoto, M., Taga, S., Akizuki, R., Endo, S., Matsunaga, T. and Ikari, A., Down-regulation of claudin-2 expression and proliferation by epigenetic inhibitors in human lung adenocarcinoma A549 cells, J. Biol. Chem., 292, 2411-2421. (2017)
  • Akizuki, R., Shimobaba, S., Matsunaga, T., Endo, S. and Ikari, A., Claudin-5, -7, and -18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma. Biochim. Biophys. Acta., 1864, 293-302 (2017)
  • Morikawa, Y., Shibata, A., Okumura, N., Ikari, A., Sasajima, Y., Suenami, K., Sato, K., Takekoshi, Y., El-Kabbani, O. and Matsunaga, T., Sibutramine provokes apoptosis of aortic endothelial cells through altered production of reactive oxygen and nitrogen species. Toxicol. Appl. Pharmacol., 314, 1-11 (2017)

2016年

  • Sugatani J, Noguchi Y, Hattori Y, Yamaguchi M, Yamazaki Y, Ikari A., Threonine-408 Regulates the Stability of Human Pregnane X Receptor through Its Phosphorylation and the CHIP/Chaperone-Autophagy Pathway. Drug Metab. Dispos., 44, 137-50 (2016)
  • Fujii, N., Matsuo, Y., Matsunaga, T., Endo, S., Sakai, H., Yamaguchi, M., Yamazaki, Y., Sugatani, J. and Ikari, A., Hypotonic stress-induced down-regulation of claudin-1 and -2 mediated by dephosphorylation and clathrin-dependent endocytosis in renal tubular epithelial cells. J. Biol. Chem., 291, 24787-24799 (2016)
  • Matsunaga, T., Saito, H., Endo, S., Iguchi, K., Soda, M., El-Kabbani, O., Hara, A. and Ikari, A., Roles of aldo-keto reductase 1B10 and 1C3 and ATP-binding cassette transporter in docetaxel tolerance. Free Radic. Res., 50, 1296-1308 (2016)
  • Matsunaga, T., Suzuki, A., Kezuka, C., Okumura, N., Iguchi, K., Inoue, I., Soda, M., Endo, S., El-Kabbani, O., Hara, A. and Ikari, A., Aldo-keto reductase 1B10 promotes development of cisplatin resistance in gastrointestinal cancer cells through down-regulating peroxisome proliferator-activated receptor-g-dependent mechanism. Chem. Biol. Interact., 256, 142-153 (2016)
  • Endo, S., Miyagi, N., Matsunaga, T., Hara, A. and Ikari, A. Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenase. Biochem. Biophys. Res. Commun., 472, 231-236 (2016)
  • Shimobaba, S., Taga, S., Akizuki, R., Endo, S., Matsunaga, T., Watanabe, R., Yamaguchi, M., Yamazaki, Y., Sugatani, J. and Ikari, A. Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 in human lung adenocarcinoma A549 cells. Biochim. Biophys. Acta., 1863, 1170-1178 (2016)

2015年

  • Ikari, A., Taga, S., Watanabe, R., Sato, T., Shimobaba, S., Sonoki, H., Endo, S., Matsunaga, T., Sakai, H., Yamaguchi, M., Yamazaki, Y. and Sugatani, J. Clathrin-dependent endocytosis of claudin-2 by DFYSP peptide causes lysosomal damage in lung adenocarcinoma A549 cells. Biochim. Biophys. Acta., 1848, 2326-2336 (2015)
  • Matsunaga T, Kezuka C, Morikawa Y, Suzuki A, Endo S, Iguchi K, Miura T, Nishinaka T, Terada T, El-kabbani O, Hara A, Ikari A. Up-regulation of carbonyl reductase 1 renders development of doxorubicin resistance in human gastrointestinal cancers. Biol. Pharm. Bull., 13, 7487-7499 (2015)
  • Hu, D., Miyagi, N., Arai, Y., Oguri, H., Miura, T., Nishinaka, T., Terada, T., Gouda, H., El-Kabbani, O., Xia, S., Toyooka, N., Hara, A., Matsunaga, T., Ikari, A. and Endo, S., Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1. Org. Biomol. Chem., 13, 7487-7499 (2015)
  • Endo, S., Noda, M., Ikari, A., Tatematsu, K., El-Kabbani, O., Hara, A., Kitade, Y. and Matsunaga, T., Characterization of hamster NAD+-dependent 3(17)β-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily. J. Biochem., 158, 425-434. (2015)
  • Yamazaki Y, Yasui K, Hashizume T, Suto A, Mori A, Murata Y, Yamaguchi M, Ikari A, Sugatani J. Involvement of a cyclic AMP-dependent signal in the diet-induced canalicular trafficking of ATP-binding cassette transporter g5/g8. Hepatology, 62,1215-26 (2015)
  • Sonoki H, Sato T, Endo S, Matsunaga T, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A. Quercetin decreases claudin-2 expression mediated by up-regulation of microRNA miR-16 in lung adenocarcinoma A549 cells. Nutrients, 7, 4578-4592 (2015)
  • Ikari, A., Fujii, N., Hahakabe, S., Hayashi, H., Yamaguchi, M., Yamazaki, Y., Endo, S., Matsunaga, T. and Sugatani, J. Hyperosmolarity-Induced Down-Regulation of Claudin-2 Mediated by Decrease in PKCβ-Dependent GATA-2 in MDCK Cells. J. Cell. Physiol., 230, 2776-2787 (2015)
  • Morikawa, Y., Kezuka, C., Endo, S., Ikari, A., Soda, M., Yamamura, K., Toyooka, N., El-Kabbani, O., Hara, A. and Matsunaga, T. Acquisition of doxorubicin resistance facilitates migrating and invasive potentials of gastric cancer MKN45 cells through up-regulating aldo–keto reductase 1B10, Chem. Biol. Interact., 250, 30-39 (2015)
  • Yamaguchi, M., Matsui, M., Higa, R., Yamazaki, Y., Ikari, A., Miyake, M., Miwa, M., Ishii, S., Sugatani, J. and Shimizu T.., A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation, Biochem. Pharmacol., 93, 482-495 (2015)
  • Endo, S., Matsunaga, T., Ikari, A., El-Kabbani, O., Hara A and Kitade, Y., Phenylalanine 217 of rabbit aldo-keto reductase (AKR1C33) is a determinant for its strict NADP(H)-specificity and high sensitivity to a mixed-type inhibitor deoxycorticosterone, Arch. Biochem. Biophys., 569, 19-25 (2015)
  • Takayanagi, K., Shimizu, T., Tayama, Y., Ikari, A., Anzai, N., Iwashita, T., Asakura, J., Hayashi, K., Mitarai, T. and Hasegawa, H., Down-regulation of transient receptor potential (TRP) M6 channel as a cause of hypermagnesiuric hypomagnesemia in obese type-2 diabetic rats, Am. J. Physiol. Renal. Physiol., 308, 1386-1397 (2015)
  • Arai, Y., Endo, S., Miyagi, N., Abe, N., Miura, T., Nishinaka, T., Terada, T., Oyama, M., Goda, H., El-Kabbani, O., Hara, A., Matsunaga, T. and Ikari, A., Structure-activity relationship of flavonoids as potent inhibitors of carbonyl reductase 1 (CBR1), Fitoterapia,101, 51-56 (2015)
  • Endo, S., Nishiyama, A., Suyama, M., Takemura, M., Soda, M., Huayue, C., Tajima, K., El-Kabbani, O., Bunai, Y., Hara, A., Matsunaga, T. and Ikari, A., Protective roles of aldo-keto reductase 1B10 and autophagy against toxicity induced by p-quinone metabolites of tert-butylhydroquinone in lung cancer A549 cells, Chem. Biol. Interact., 234, 282-289 (2015)

2014年

  • Endo, S., Arai, Y., Matsunaga, T., Ikari, A., El-Kabbani, O., Hara, A. and Kitade, Y., AKR1C30 and AKR1C31 with Site-Directed Mutagenesis: Identifying the Roles of Residues 54 and 56 in the Binding of Substrates and Inhibitors, Biol. Pharm. Bull., 37, 1848-1852 (2014)
  • 遠藤智史、松永俊之、五十里彰, 大豆イソフラボンによる肺癌リスク軽減効果の性差発現機序の解明, 大豆たん白質研究, 35, 159-163 (2014)
  • Matsunaga, T., Yamaji, Y., Tomokuni, T., Morita, H., Morikawa, Y., Suzuki, A., Yonezawa, A., Endo, S., Ikari, A., Iguchi, K., El-Kabbani, O., Tajima, K. and Hara, A., Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome, Free Radic. Res., 48, 1371-1385 (2014)
  • Endo, S., Hu, D., Matsunaga, T., Otsuji, Y., El-Kabbani, O., Kandeel, M., Ikari, A., Hara, A., Kitade, Y. and Toyooka, N., Synthesis of non-prenyl analogues of baccharin as selective and potent inhibitors for aldo-keto reductase 1C3, Bioorg. Med. Chem., 22, 5220-5233 (2014)
  • Sugatani, J., Hattori, Y., Noguchi, Y., Yamaguchi, M., Yamazaki, Y. and Ikari, A., Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1., Drug Metab. Dispos., 42, 1708-1718 (2014)
  • Ikari, A., Watanabe, R., Sato, T., Taga, S., Shimobaba, S., Yamaguchi, M., Yamazaki, Y., Endo, S., Matsunaga, T and Sugatani, J., Nuclear distribution of claudin-2 increases cell proliferation in human lung adenocarcinoma cells, Biochim. Biophys. Acta, 1843, 2079-2088 (2014)
  • Matsunaga, T., Morikawa, Y., Haga, M., Endo, S., Soda, M., Yamamura K., El-Kabbani, O., Tajima, K., Ikari, A. and Hara, A., Exposure to 9,10-phenanthrenequinone accelerates malignant progression of lung cancer cells through up-regulation of aldo-keto reductase 1B10, Toxicol. Appl. Pharmacol., 278, 180-189 (2014)
  • Matsunaga, T., Yamaguchi, A., Morikawa, Y., Kezuka, C., Takazawa, H., Endo, S., El-Kabbani, O., Tajima, K., Ikari, A. and Hara, A., Induction of aldo-keto reductases (AKR1C1 and AKR1C3) abolishes the efficacy of daunorubicin chemotherapy for leukemic U937 cells, Anticancer Drugs, 25, 868-877 (2014)
  • Ikari, A., Tonegawa, C., Sanada, A., Kimura, T., Sakai, H., Hayashi, H., Hasegawa, H., Yamaguchi, M., Yamazaki, Y., Endo, S., Matsunaga, T. and Sugatani, J., Tight Junctional Localization of Claudin-16 is Regulated by Syntaxin 8 in Renal Tubular Epithelial Cells, J. Biol. Chem., 289, 13112-13123 (2014)
  • Endo, S., Matsunaga, T., Arai, Y., Ikari, A., Tajima, K., El-Kabbani, O., Yamano, S., Bunai, Y., Hara, A. and Kitade, Y., Cloning and characterization of four rabbit aldo-keto reductases featuring broad substrate specificity for xenobiotic and endogenous carbonyl compounds: Their relationship with multiple forms of drug ketone reductases, Drug Metab. Dispos., 42, 803-812 (2014)
  • Sugatani, J., Sadamitsu, S., Yamaguchi, M., Yamazaki, Y., Higa, R., Hattori, Y., Uchida, T., Ikari, A., Sugiyama, W., Watanabe, T., Ishii, S., Miwa, M. and Shimizu, T., Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age, FASEB J., 28, 440-452 (2014)
  • Takahashi, Y., Fujii, T., Fujita, K., Shimizu, T., Higuchi, T., Tabuchi, Y., Sakamoto, H., Naito, I., Manabe, K., Uchida, S., Sasaki, S., Ikari, A., Tsukada, K. and Sakai, H., Functional coupling of chloride-proton exchanger ClC-5 to gastric H+,K+-ATPase, Biol. Open, 15, 12-21 (2014)

2013年

  • Yamazaki, Y., Yasuda, K., Matsuyama, T., Ishihara, T., Higa, R., Sawairi, T., Yamaguchi, M., Egi, M., Akai, S., Miyase, T., Ikari, A., Miwa, M. and Sugatani, J., A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice, Biochem. Pharmacol., 86, 632-644 (2013)
  • Ikari, A., Atomi, K., Yamazaki, Y., Sakai, H., Hayashi, H., Yamaguchi, M. and Sugatani, J., Hyperosmolarity-induced up-regulation of claudin-4 mediated by NADPH oxidase-dependent H2O2 production and Sp1/c-Jun cooperation, Biochim. Biophys, Acta., 1833, 2617-2627 (2013)
  • Endo, S., Hu, D., Suyama, M., Matsunaga, T., Sugimoto, K., Matsuya, Y., El-Kabbani, O., Kuwata, K., Hara, A., Kitade, Y. and Toyooka, N., Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10, Bioorg. Med. Chem., 21, 6378-6384 (2013)
  • Endo, S., Matsunaga, T., Matsumoto, A., Arai, Y., Ohno, S., El-Kabbani, O., Tajima, K., Bunai, Y., Yamano, S., Hara, A. and Kitade, Y., Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D2, and other endogenous and xenobiotic carbonyl compounds, Biochem. Pharmacol., 86, 1366-1375 (2013)
  • Endo, S., Arai, Y., Hara, A., Kitade, Y., Bunai, Y., El-Kabbani, O. and Matsunaga T., Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenase, Biol. Pharm. Bull., 36, 1514-1518 (2013)
  • Endo, S., Matsunaga, T., Fujimoto, A., Kumada, S., Arai, Y., Miura, Y., Mikamo, H., El-Kabbani, O., Yamano, S., Iinuma, M. and Hara, A., Characterization of a rabbit morphine 6-dehydrogenase and its two isoforms which function as NAD+-dependent 3α(17β)-hydroxysteroid dehydrogenases, Arch. Biochem. Biophys., 529, 131-139 (2013)
  • Endo, S., Fujimoto, A., Kumada, S., Matsunaga, T., Ohno, S., Mano, J., Tajima, K., El-Kabbani, O. and Akira Hara, Modulation of activity and inhibitor sensitivity of rabbit aldose reductase-like protein by oxidized glutathione and SH-reagents, Chem. Biol. Interact., 202, 146-152 (2013)
  • Matsunaga, T., Hojo, A., Yamane, Y., Endo, S., El-Kabbani, O. and Hara, A., Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers, Chem. Biol. Interact., 202, 234-242 (2013)

2012年

  • Ikari, A., Sato, T., Watanabe, R., Yamazaki, Y. and Sugatani, J., Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells, Biochim. Biophys, Acta., 1823, 1110-1118 (2012)
  • Ikari, A., Atomi, K., Takiguchi, A., Yamazaki, Y., Hayashi, H., Hirakawa, J. and Sugatani, J., Enhancement of cell-cell contact by claudin-4 in renal epithelial Madin-Darby canine kidney cells, J. Cell. Biochem., 113, 499-507 (2012)
  • Sugatani, J., Uchida, T., Kurosawa, M., Yamaguchi, M., Yamazaki, Y., Ikari, A. and Miwa, M., Regulation of pregnane X receptor (PXR) function and UGT1A1 gene expression by post-translational modification of PXR protein, Drug Metab. Dispos., 40, 2031-2040 (2012)
  • Sugatani, J., Sadamitsu, S., Wada, T., Yamazaki, Y., Ikari, A. and Miwa, M., Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet, Nutr. Metabol., 9, 23 (2012)
  • Soda, M., Endo, S., Matsunaga, T., Zhao, H. T., El-Kabbani, O., Iinuma, M., Yamamura, K. and Hara, A., Inhibition of Human Aldose Reductase-like Protein (AKR1B10) by α- and γ-Mangostins, Major Components of Pericarps of Mangosteen, Biol. Pharm. Bull., 35, 2075-2080. (2012)
  • Endo, S., Matsunaga, T., Kumada, S., Fujimoto, A., Ohno, S., El-Kabbani, O., Hu, D., Toyooka, N., Mano, J., Tajima, K. and Hara, A., Characterization of rabbit aldose reductase-like protein with 3beta-hydroxysteroid dehydrogenase activity, Arch. Biochem. Biophys., 527, 23-30. (2012)
  • Matsunaga, T., Hosogai, M., Arakaki, M., Endo, S., El-Kabbani, O. and Hara, A., 9,10-Phenanthrenequinone Induces Monocytic Differentiation of U937 Cells through Regulating Expression of Aldo-Keto Reductase 1C3, Biol. Pharm. Bull., 35, 1598-1602. (2012)
  • Matsunaga, T., Endo, S., Takemura, M., Soda, M., Yamamura, K., Tajima, K., Miura, T., Terada, T., El-Kabbani, O. and Hara, A., Reduction of Cytotoxic p-Quinone Metabolites of tert-Butylhydroquinone by Human Aldo-keto Reductase (AKR) 1B10, Drug Metab. Pharmacokinet., 27, 553-558. (2012)
  • Osman, W., Endo, S., Oh-Hashi, K., Kitamura, Y. and Kitade, Y., Molecular characterization and mutational analysis of recombinant diadenosine 5′,5”-P(1),P(4)-tetraphosphate hydrolase from Plasmodium falciparum, Biol. Pharm. Bull., 35, 1191-1196. (2012)
  • Endo, S., Matsunaga, T., Kanamori, A., Otsuji, Y., Nagai, H., Sundaram, K., El-Kabbani, O., Toyooka, N., Ohta, S. and Hara, A., Selective inhibition of human type-5 17beta-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis, J. Nat. Prod., 75, 716-721. (2012)
  • Sundaram, K., Endo, S., Matsunaga, T., Tanaka, N., Hara, A. and El-Kabbani, O., Structure of the His269Arg mutant of the rat aldose reductase-like protein AKR1B14 complexed with NADPH, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 68, 400-403. (2012)
  • Matsunaga, T., Haga, M., Watanabe, G., Shinoda, Y., Endo, S., Kajiwara, Y., Tanaka, H., Inagaki, N., El-Kabbani, O. and Hara, A., 9,10-Phenanthrenequinone promotes secretion of pulmonary aldo-keto reductases with surfactant, Cell Tissue Res., 347, 407-417. (2012)
  • Soda, M., Hu, D., Endo, S., Takemura, M., Li, J., Wada, R., Ifuku, S., Zhao, H. T., El-Kabbani, O., Ohta, S., Yamamura, K., Toyooka, N., Hara, A. and Matsunaga, T., Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10, Eur. J. Med. Chem., 48, 321-329. (2012)
  • Minehira, D., Takeda, D., Urata, H., Kato, A., Adachi, I., Wang, X., Matsuya, Y., Sugimoto, K., Takemura, M., Endo, S., Matsunaga, T., Hara, A., Koseki, J., Narukawa, K., Hirono, S. and Toyooka, N., Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-beta-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1, Bioorg. Med. Chem., 20, 356-367. (2012)

2011年

  • Ikari, A., Sanada, A., Sawada, H., Okude, C., Tonegawa, C. and Sugatani, J., Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells, Biochim. Biophys. Acta., 1808, 1502-1508 (2011)
  • Ikari, A., Takiguchi, A., Atomi, K., Sato, T. and Sugatani, J., Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby canine kidney cells, J. Cell. Physiol., 226, 1471-1478 (2011)
  • Ikari, A., Takiguchi, A., Atomi, K. and Sugatani, J., Epidermal growth factor increases clathrin-dependent endocytosis and degradation of claudin-2 protein in MDCK II cells, J. Cell. Physiol., 226, 2448-2456 (2011)
  • Ikari, A., Sato, T., Takiguchi, A., Atomi, K., Yamazaki, Y. and Sugatani, J., Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cells, Life Sci., 88, 628-633 (2011)
  • Ikari, A., Sawada, H., Sanada, A., Tonegawa, C., Yamazaki, Y. and Sugatani, J., Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21Cip1 and p27Kip1 in renal epithelial NRK-52E cells, J. Cell. Biochem., 112, 3563-3572 (2011)
  • Yamazaki, Y., Hashizume, T., Morioka, H., Sadamitsu, S., Ikari, A., Miwa, M. and Sugatani, J., Diet-induced lipid accumulation in liver enhances ATP-binding cassette transporter g5/g8 expression in bile canaliculi, Drug Metab. Pharmacokinet., 26, 442-450 (2011)
  • Matsunaga, T., Shinoda, Y., Inoue, Y., Shimizu, Y., Haga, M., Endo, S., El-Kabbani, O. and Hara, A., Aldo-keto reductase 1C15 as a quinone reductase in rat endothelial cell: its involvement in redox cycling of 9,10-phenanthrenequinone, Free Radic. Res., 45, 848-857. (2011)
  • Endo, S., Matsunaga, T., Fujita, A., Kuragano, T., Soda, M., Sundaram, K., Dhagat, U., Tajima, K., El-Kabbani, O. and Hara, A., Activation of aldo-keto reductase family member 1B14 (AKR1B14) by bile acids: Activation mechanism and bile acid-binding site, Biochimie, 93, 1476-1486. (2011)
  • Takemura, M., Endo, S., Matsunaga, T., Soda, M., Zhao, H. T., El-Kabbani, O., Tajima, K., Iinuma, M. and Hara, A., Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid, J. Nat. Prod., 74, 1201-1206. (2011)
  • El-Kabbani, O., Dhagat, U., Soda, M., Endo, S., Matsunaga, T. and Hara, A., Probing the inhibitor selectivity pocket of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis, Bioorg. Med. Chem. Lett., 21, 2564-2567. (2011)
  • Matsunaga, T., Yamane, Y., Iida, K., Endo, S., Banno, Y., El-Kabbani, O. and Hara, A., Involvement of the aldo-keto reductase, AKR1B10, in mitomycin-c resistance through reactive oxygen species-dependent mechanisms, Anticancer Drugs, 22, 402-408. (2011)
  • Matsunaga, T., Shinoda, Y., Inoue, Y., Endo, S., El-Kabbani, O. and Hara, A., Protective effect of rat aldo-keto reductase (AKR1C15) on endothelial cell damage elicited by 4-hydroxy-2-nonenal, Chem. Biol. Interact., 191, 364-370. (2011)
  • Endo, S., Matsunaga, T., Ohta, C., Soda, M., Kanamori, A., Kitade, Y., Ohno, S., Tajima, K., El-Kabbani, O. and Hara, A., Roles of rat and human aldo-keto reductases in metabolism of farnesol and geranylgeraniol, Chem. Biol. Interact., 191, 261-268. (2011)
  • Tabuchi, M., Seo, M., Inoue, T., Ikeda, T., Kogure, A., Inoue, I., Katayama, S., Matsunaga, T., Hara, A. and Komoda, T., Anal. Chem., 83, 1131-1136 (2011)

2010年

  • Sugatani, J., Sadamitsu, S., Kurosawa, M., Ikushiro, S., Sakaki, T., Ikari, A. and Miwa, M., Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats, Drug Metab. Dispos., 38, 1655-1664 (2010)
  • Ikari, A., Sanada, A., Okude, C., Sawada, H., Yamazaki, Y., Sugatani, J. and Miwa, M., Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells, J. Cell. Physiol., 222, 481-487 (2010)
  • Ikari, A., Kinjo, K., Atomi, K., Sasaki, Y., Yamazaki, Y. and Sugatani, J., Extracellular Mg2+ regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylation, Biochim. Biophys. Acta., 1798, 415-421 (2010)
  • Ikari, A., Atomi, K., Kinjo, K., Sasaki, Y. and Sugatani, J., Magnesium deprivation inhibits a MEK-ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells, Life Sci., 86, 766-773 (2010)
  • Sugatani, J., Osabe, M., Kurosawa, M., Kitamura, N., Ikari, A. and Miwa, M., Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: cell cycle-dependent expression, Drug Metab. Dispos., 38, 177-186 (2010)
  • Endo, S., Matsunaga, T., Fujita, A., Tajima, K., El-Kabbani, O. and Hara, A., Rat aldose reductase-like protein (AKR1B14) efficiently reduces the lipid peroxidation product 4-oxo-2-nonenal, Biol. Pharm. Bull., 33, 1886-1890. (2010)
  • El-Kabbani, O., Scammells, P. J., Day, T., Dhagat, U., Endo, S., Matsunaga, T., Soda, M. and Hara, A., Structure-based optimization and biological evaluation of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors, Eur. J. Med. Chem., 45, 5309-5317. (2010)
  • Endo, S., Matsunaga, T., Kuragano, T., Ohno, S., Kitade, Y., Tajima, K., El-Kabbani, O. and Hara, A., Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10), Arch. Biochem. Biophys., 503, 230-237. (2010)
  • Dhagat, U., Endo, S. (#Equal first author contribution), Soda, M., Hara, A. and El-Kabbani, O., Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme, Bioorg. Med. Chem. Lett., 20, 5274-5276. (2010)
  • Asada, Y., Kuroishi, C., Ukita, Y., Sumii, R., Endo, S., Matsunaga, T., Hara, A. and Kunishima, N., Dimeric crystal structure of rabbit L-gulonate 3-dehydrogenase/lambda-crystallin: insights into the catalytic mechanism, J. Mol. Biol., 401, 906-920. (2010)
  • Zhao, H. T., Soda, M., Endo, S., Hara, A. and El-Kabbani, O., Selectivity determinants of inhibitor binding to the tumour marker human aldose reductase-like protein (AKR1B10) discovered from molecular docking and database screening, Eur. J. Med. Chem., 45, 4354-4357. (2010)
  • Endo, S., Matsunaga, T., Soda, M., Tajima, K., Zhao, H. T., El-Kabbani, O. and Hara, A., Selective inhibition of the tumor marker AKR1B10 by antiinflammatory N-phenylanthranilic acids and glycyrrhetic acid, Biol. Pharm. Bull., 33, 886-890. (2010)
  • Endo, S., Matsunaga, T., Kuwata, K., Zhao, H. T., El-Kabbani, O., Kitade, Y. and Hara, A., Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10, Bioorg. Med. Chem., 18, 2485-2490. (2010)
  • Matsunaga, T., Arakaki, M., Kamiya, T., Haga, M., Endo, S., El-Kabbani, O. and Hara, A., Nitric oxide mitigates apoptosis in human endothelial cells induced by 9,10-phenanthrenequinone: role of proteasomal function, Toxicology, 268, 191-197. (2010)
  • Matsunaga, T., Tsuji, Y., Kaai, K., Kohno, S., Hirayama, R., Alpers, D., Komoda, T. and Hara, A., Cancer Chemother. Pharmacol., 66, 517-526 (2010)
  • Ikeda, T., Seo M., Inoue I., Katayama, S., Matsunaga, T., Hara, A. Komoda, T. and Tabuchi M., Anal. Chem., 82, 1128-1132 (2010)
  • Dhagat, U., Endo, S. (#Equal first author contribution), Mamiya, H., Hara, A. and El-Kabbani, O., Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme, Acta Crystallogr. D Biol. Crystallogr., 66, 198-204. (2010)

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