Gifu, Japan

Cosmetic Health Science

Research Interests

Due to remarkable advances in the medical and health fields as well as improvement in the social environment and lifestyle habits, we have now entered the age of longevity, and demand a high quality of life (QOL) with a healthy long life. In addition to having a sound body and mind, another important factor for a person’s well-being is to appear younger and more attractive than one actually. Recently, it has been reported that younger perceived age or estimated age is related to maintain physiological functions of one’s entire body including one’s skin, at levels higher than those of other people of the same age, however it remains obscure scientifically. We aim to contribute to achieve “Beauty and Health” by elucidating scientifically the relationship between changes in conditions of systemic health such as aging, lifestyle-related diseases, chronic inflammation, and senescence, and functional alterations of the skin. In addition, we propose new values of cosmetic and food ingredients by estimating function, safety, and social significance such as QOL improvement and preventive medicine in a viewpoint of skin science.

Research Objectives
  1. Research on endogeneous mediators related to skin health essential for skin beauty
  2. Clarification of the relationship between chronic inflammation and skin aging by in vitro cultured cell systems
  3. Elucidation of mechanism for melanocyte specific cytotoxicity in chemical-induced depigmentaion
Research Results
  1. Kondo M, Kawabata K, Sato K, Yamaguchi S, Hachiya A, Takahashi Y, Inoue S., Glutathione maintenance is crucial for survival of melanocytes after exposure to rhododendrol. Pigment Cell Melanoma Res. 29, 541-549 (2016)
  2. Nagaoka A, Yoshida H, Nakamura S, Morikawa T, Kawabata K, Kobayashi M, Sakai S, Takahashi Y, Okada Y, Inoue S., Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts. J Biol Chem. 290, 30910-30923 (2015)
  3. Sasaki M, Kondo M, Sato K, Umeda M, Kawabata K, Takahashi Y, Suzuki T, Matsunaga K, Inoue S., Rhododendrol, a depigmentation-inducing phenolic compound, exerts melanocyte cytotoxicity via a tyrosinasedependent mechanism. Pigment Cell Melanoma Res. 27, 754-763 (2014)
  4. Yoshida H, Nagaoka A, Nakamura S, Tobiishi M, Sugiyama Y, Inoue S., N-Terminal signal sequence is required for cellular trafficking and hyaluronan-depolymerization of KIAA1199. FEBS Lett. 588, 111-116 (2014)
  5. Yoshida H, Nagaoka A, Kusaka-Kikushima A, Tobiishi M, Kawabata K, Sayo T, Sakai S, Sugiyama Y, Enomoto H, Okada Y, Inoue S., KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization. Proc Natl Acad Sci U S A. 110, 5612-5617 (2013)
  6. Yuki T, Komiya A, Kusaka A, Kuze T, Sugiyama Y, Inoue S., Impaired tight junctions obstruct stratum corneum formation by altering polar lipid and profilaggrin processing. J Dermatol Sci. 69, 148-158 (2013)
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