Gifu, Japan

Clinical Pharmaceutics

Research Interests

Our laboratory is interested in how oxidative stress is related to the onset and/or progression of various diseases including diabetes, atherosclerosis and neurodegenerative disorders. Oxygen is essential for prokaryotic and eukaryotic cells to obtain energy. However, reactive oxygen species (ROS) are generated as by-products of cellular metabolism of oxygen even under normal physiological conditions. These molecules are high reactive and cause oxidative damage to cellular components, resulting in cytotoxicity. To avoid oxidative damage, cells with the antioxidative defense systems such as antioxidants and enzymes generate ROS scavenging activity, such as superoxide dismutase (SOD). Oxidative stress is caused by an imbalance between production of ROS and the anti-oxidative defense systems. On the other hand, however, recent reports have demonstrated that ROS serve as signaling molecules for altering the redox state of specific target molecules that affect cellular functions. Our current works focus on redox regulation of cell signaling under pathological conditions and epigenetic regulation of gene expression of anti-oxidative enzymes.

Research Objectives
  1. Regulation of EC-SOD gene expression by GLP-1 analog
  2. Molecular mechanism of cellular response to non-thermal atmospheric pressure plasma
  3. Exploratory study of anti-oxidative and anti-inflammatory compounds
  4. Zinc signaling related to neurotoxicity
  5. Epigenetic regulation of anti-oxidative enzymes
Research Results
  1. Yasuda H., Mizukami K., Hayashi M., Kamiya T., Hara H., Adachi T., Exendin-4 promotes extracellular-superoxide dismutase expression in A549 cells through DNA demethylation, J. Clin. Biochem. Nutr. 58, 34-39 (2016).
  2. Hara H., Taniguchi M., Kobayashi M., Kamiya T., Adachi T., Plasma-activated medium-induced intracellular zinc liberation causes death of SH-SY5Y cells, Arch. Biochem. Biophys. 584, 51-60 (2015).
  3. Adachi T., Tanaka H., Nonomura S., Hara H., Kondo S., Hori M., Plasma-activated medium induced A549 cell injury by a spiral apoptotic cascade involving the mitochondrial-nuclear network, Free Rad. Biol. Med. 79, 28-44 (2015).
  4. Makino J., Nii M., Kamiya T., Hara H., Adachi T., Oxidized low-density lipoprotein accelerates the destabilization of extracellular-superoxide dismutase mRNA during foam cell formation, Arch. Biochem. Biophys. 575, 54-60 (2015).
  5. Kamiya T., Machiura M., Makino J., Hara H., Hozumi I., Adachi T., Epigenetic regulation of extracellular-superoxide dismutase in human monocytes, Free Radic. Biol. Med. 61C, 197-205 (2013).
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